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International Journal of Clinical Nutrition & Dietetics Volume 2 (2016), Article ID 2:IJCND-108, 5 pages
https://doi.org/10.15344/2456-8171/2016/108
Research Article
Lactobacillus paracasei NFRI 7415 Reduces Liver Lipid Contents in C57BL/6J Mice Fed a High-fat Diet

Noriko Komatsuzaki1*, Yumiko Yamada2, Yukihide Ueki1, Jun Shima3 and Shunichi Morikawa4

1Department of Human Nutrition, Seitoku University, 550 Iwase, Matsudo, Chiba 271-8555, Japan
2Nodakamada Gakuen, 389-1 Noda, Noda, Chiba 278-0037, Japan
3Faculty of Agriculture, Ryukoku University, 1-5 Yokotani, Seta Oe-cho, Otsu, Shiga 520-2194, Japan
4Department of Anatomy and Developmental Biology, Tokyo Women’s Medical University, 8-1 Kawada-Cho, Shinjuku, Tokyo 162-8666, Japan
Dr. Noriko Komatsuzaki, Department of Human Nutrition, Seitoku University, 550 Iwase, Matsudo, Chiba 271-8555, Japan, Fax: +81-47-363-1401; E-mail: norikoma@seitoku.ac.jp
17 April 2016; 16 June 2016; 18 June 2016
Komatsuzaki N, Yamada Y, Ueki Y, Shima J, Morikawa S (2016) Lactobacillus paracasei NFRI 7415 Reduces Liver Lipid Contents in C57BL/6J Mice Fed a High-fat Diet. Int J Clin Nutr Diet 2: 108. doi: https://doi.org/10.15344/2456-8171/2016/108

Abstract

We examined the effects of Lactobacillus paracasei NFRI 7415 isolated from Japanese fermented fish (funa-sushi) on the whole-body and fat-tissue weights, plasma lipid concentration and hepatic lipid contents of mice. Male C57BL/6J mice were fed a control diet (CD), high-fat diet (HD) or HD containing Lb. paracasei NFRI 7415 (106 cfu/g) (HLD) for 10 weeks. The plasma triacylglycerol concentration of the HLD group was lower than that of the HD group. The plasma glucose, leptin and hepatic lipid concentration of the CD and LHD groups were lower than those of the HD group. As a result of measuring the liver lipids and the liver histology, it was observed that the number of lipid droplets in liver cells in the HD group was clearly greater than that in the CD and HLD groups. The total liver lipids in the CD and HLD group were lower than that of the HD group. This suggests that intake of Lb. paracasei NFRI 7415 is effective in overcoming the effects of HD to prevent hepatic lipid accumulation.