Discovery of Oosporein as a New Inhibitor of Influenza Virus Cap-snatching Activity

doi:10.15344/2394-1502/2020/137

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International Journal of Pharmaceutical Sciences Research Volume 7 (2020), Article ID 7:IJPSR-137, 2 pages
https://doi.org/10.15344/2394-1502/2020/137

Short Communication

Discovery of Oosporein as a New Inhibitor of Influenza Virus Cap-snatching Activity

Nobuhiro Koyama^1,2*, Yoshio Shibagaki³, Mitsuru Okuwaki³, Seisuke Hattori³ and Hiroshi Tomoda^1,2*

¹Department of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, Japan
²Medicinal Research Laboratories, School of Pharmacy, Kitasato University, Japan
³Division of Biochemistry, School of Pharmacy, Kitasato University, Japan

Corresponding Author Details: Dr. Nobuhiro Koyama, Department of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan; E-mail: koyaman@pharm.kitasato-u.ac.jp

Corresponding Author Details: Dr. Hiroshi Tomoda, Department of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan; E-mail: tomodah@pharm.kitasato-u.ac.jp

Received: 10 June 2020; Accepted: 04 July 2020; Published: 05 July 2020

Citation: Koyama N, Shibagaki Y, Okuwaki M, Hattori S, Tomoda H, et al. (2020) Discovery of Oosporein as a New Inhibitor of Influenza Virus Cap-snatching Activity. Int J Pharma Sci Res 7: 137. doi: https://doi.org/10.15344/2456-4028/2020/137

Funding: This work was supported by grant 15K07867 (NK) from the Ministry of Education, Culture, Sport, Science, and Technology, Japan.

Copyright: © 2020 Mal et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

During our screening of microbial origins, we found that fungal strain BF-0073 produces an inhibitor of the cap-snatching activity of influenza virus. Compound (1) was isolated from the culture broth of fungal strain BF-0073 by solvent extraction and preparative HPLC. Based on structural analyses using MS and NMR, 1 was identified as oosporein. Compound 1 inhibited the cap-snatching activity of influenza virus A in a dose-dependent manner, with an IC₅₀ value of 20.0 μg/mL.

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