Analysis of Recurrent Stroke Volume Between VKA (Vitamin K Antagonist) and Three NOACs (Non-Vitamin K Antagonist Oral Anticoagulants) Under Oral Anticoagulant Therapy

doi:10.15344/2394-1502/2016/116

Graphy

Profile

New User

New to Graphy Publications? Create an account to get started today.

Create Account For:

Registered Users

Have an account? Sign in now.

Article Menu

Journal Menu

How to Cite | Author Information | Publication History

International Journal of Pharmaceutical Sciences Research Volume 3 (2016), Article ID 3:IJPSR-116, 6 pages
http://dx.doi.org/10.15344/2394-1502/2016/116

Original Article

Analysis of Recurrent Stroke Volume between VKA (Vitamin K Antagonist) and Three NOACs (Non-Vitamin K Antagonist Oral Anticoagulants) under Oral Anticoagulant Therapy

Hiroaki Oguro^1*, Ryo Mizuhara¹, Satoshi Abe¹, Hiroyuki Takayoshi¹, Shingo Mitaki¹, Keiichi Onoda¹, Atsushi Nagai² and Shuhei Yamaguchi¹

¹Department of Neurology, Shimane University, Faculty of Medicine, 1060 Nishikawatsucho, Matsue, Shimane Prefecture 690-8504, Japan
²Department of Laboratory Medicine, Shimane University, Faculty of Medicine, 1060 Nishikawatsucho, Matsue, Shimane Prefecture 690-8504, Japan

Corresponding Author Details: Prof. Hiroaki Oguro, Department of Neurology, Shimane University Hospital, 89-1 Enya-cho, Izumo city, Shimane 693-8501, Japan; E-mail: oguro@med.shimane-u.ac.jp

Received: 01 November 2016; Accepted: 10 December 2016; Published: 12 December 2016

Citation: Oguro H, Mizuhara R, Abe S, Takayoshi H, Mitaki S, et al. (2016) Analysis of Recurrent Stroke Volume between VKA (Vitamin K Antagonist) and Three NOACs (Non-Vitamin K Antagonist Oral Anticoagulants) under Oral Anticoagulant Therapy. Int J Pharma Sci Res 3: 116. doi: https://doi. org/10.15344/2394-1502/2016/116

Copyright: © 2016 Oguro et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: We investigated recurrent stroke volume with nonvalvular atrial fibrillation (NVAF) patients treated with non-vitamin K antagonist oral anticoagulants (NOACs) about clinical backgrounds and number of recurrent stroke.
Methods: We administered three NOACs, dabigatran, rivaroxaban and apixaban in 84 post cardioembolic stroke with NVAF. In retrospective study, we measured recurrent stroke volume with MRI volumetry soft and compared them between 7 vitamin K anticoagulant (VKA: warfarin) cases and 10 NOACs cases under anticoagulant therapy.
Results: Of 84 cases, 27 cases were started with VKA and switched to NOACs after 7 recurrent stroke. Other 57 cases were directly started with NOACs and 10 cases with NOACs as first anticoagulants had recurrent stroke. The frequency of recurrent stroke during anticoagulant therapy are not different among VKA group and three NOACs group. Recurrent stroke volume is significantly larger in VKA group (27.4 cm3) than in NOACs group (3.3cm³).
Conclusions: Secondary prevention with NOACs after stroke might be more beneficial by reducing recurrent infarct volume than VKA.

Best viewed in Mozilla Firefox, Google Chrome, Safari, Above IE 9.0 version