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International Journal of Pharmaceutical Sciences Research Volume 3 (2016), Article ID 3:IJPSR-114, 5 pages
http://dx.doi.org/10.15344/2394-1502/2016/114
Research Article
In vitro evaluation of permeation ability and in vivo whitening of ascorbic acid 2-glucoside in microemulsion

Cheng-Chou Lin1, Yu-Chih Lin2, Ming-Yi Gao3 and Yi-Ping Fang4*

1Kalin Enterprise Co., Ltd, Taipei, Taiwan
2Department of Environmental Engineering and Health, College of Health Sciences, Yuanpei University of Medical Technology, Hsinchu, Taiwan
3Department of Biotechnology, College of Health Sciences, Yuanpei University of Medical Technology, Hsinchu, Taiwan
4School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
Prof. Yi-Ping Fang, 100, Shih-Chuan 1st Road, San Ming District, Kaohsiung, Taiwan, 80708, Tel: +886-7-3121101 (Ext. 2261), Fax:+886-7-3210683; E-mail: ypfang@kmu.edu.tw
02 September 2016; 13 October 2016; 15 October 2016
Lin CC, Lin YC, Gao MY, Fang YP (2016) In vitro evaluation of permeation ability and in vivo whitening of ascorbic acid 2-glucoside in microemulsion. Int J Pharma Sci Res 3: 114. doi: http://dx.doi.org/10.15344/2394-1502/2016/114

Abstract

Ascorbic Acid 2-Glucoside (AA2G), l-ascorbic acid derivatives, is provided whitening, anti-oxidation effect and more stable in physicochemical properties. AA2G used in the cosmetic industrial area, however, it hydrophilic character caused lower ability across stratum corneum to the skin, the whitening effect was limited. A microemulsions is the best choice in the study due to the scale up easily in the cosmetic industrial. We aim to optimized microemulsion formulation which easily preparation and stabilized in the cosmetic industrial and enhance the penetration ability into skin simultaneous remain lightening effect. AA2G microemulsion was prepared archive approximately 150 nm. The results showed that the AA2G microemulsion has powerful permeation ability and high skin deposition when compared with the AA2G aqueous control solution and the commercial emulsion product (p<0.05). In human study demonstrated that AA2G microemulsion group could archived lightening (c*) and colorful (e*) by colormery evaluation. The results support that AA2G microemulsion as a potential carrier application in the cosmetic industrial.