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International Journal of Clinical Nutrition & Dietetics Volume 4 (2018), Article ID 4:IJCND-135, 7 pages
https://doi.org/10.15344/2456-8171/2018/135
Research Article
Effects of Anti-oxidants on Oxidative Stress: Assessing MDA in Urine Samples

Sundardas Dharmadas Annamalay

Natural Therapies Research Centre, Victoria Street, Bugis Village, Singapore
Dr. Sundardas Dharmadas Annamalay, Natural Therapies Research Centre, Victoria Street, Bugis Village, Singapore 188035; E-mail: sundardasa@gmail.com
09 June 2018; 15 August 2018; 17 August 2018
Annamalay SD (2018) Effects of Anti-oxidants on Oxidative Stress: Assessing MDA in Urine Samples. Int J Clin Nutr Diet 4: 135. doi: https://doi.org/10.15344/2456-8171/2018/135

References

  1. Aruoma OI (1998) Free radicals, Oxidative stress ad antioxidants in human health and disease. J Am Oil Chem Soc 75: 199-212 [CrossRef] [Google Scholar]
  2. Orrenius S, McConkey DJ, Bellomo G, Nicotera P (1989) Role of Ca2+ in Toxic Cell Killing. Trends Pharamacol Sci 10: 281-285 [CrossRef] [Google Scholar] [PubMed]
  3. Michiels C, Remacle J (1991) Cytotoxicity of linoleic acid peroxide, malondialdehyde and 4-hydroxynonenal towards human fibroblasts. Toxicology 66: 225-234 [CrossRef] [Google Scholar] [PubMed]
  4. Brammer JP, Kerecsen L, Maguire M (1982) Effects of vinblastine on malondialdehyde formation, serotonin release and aggregation in human platelets. Eur J Pharmacol 81: 577-585 [CrossRef] [Google Scholar] [PubMed]
  5. Smith JB, Ingerman CM, Silver MJ (1976) Malondialdehyde formation as an indicator of prostaglandin production by human platelets. J Lab Clin Med 88: 167-172 [Google Scholar] [PubMed]
  6. IARC (1985) IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Allyl Compounds, Aldehydes, Epoxides and Peroxides, Lyon 36: 163-177
  7. United States National Library of Medicine (1997) Hazardous Substances Data Bank (HSDB), Bethesda, MD Record No. 4353
  8. Chole RH, Patil RN, Basak A, Palandurkar K, Bhowate R, et al. (2010) Estimation of serum malondialdehyde in oral cancer and precancer and its association with healthy individuals, gender, alcohol, and tobacco abuse. J Cancer Res Ther 6: 487-491 [CrossRef] [Google Scholar] [PubMed]
  9. Zhang Y, Chen SY, Hsu T, Santella RM (2002) Immunohistochemical detection of malondialdehyde-DNA adducts in human oral mucosa cells. Carcinogenesis 23: 207-211 [CrossRef] [Google Scholar] [PubMed]
  10. Mateos R, Goya L, Bravo L (2004) Determination of malondialdehyde by liquid chromatography as the 2, 4-dinitrophenylhydrazone derivative: a marker for oxidative stress in cell cultures of human hepatoma HepG2. J Chromatogr B Analyt Technol Biomed Life Sci 805: 33-39 [CrossRef] [Google Scholar] [PubMed]
  11. Korchazhkina O, Exley C, Andrew, SS (2003) Measurement by reversedphase high-performance liquid chromatography of malondialdehyde in normal human urine following derivatisation with 2,4-dinitrophenylhydrazine. J Chromatogr B Analyt Technol Biomed Life Sci 794: 353-362 [CrossRef] [Google Scholar] [PubMed]
  12. Volpi N, Tarugi P (1998) Improvement in the high-performance liquid chromatography malondialdehyde level determination in normal human plasma. J Chromatogr B Biomed Sci Appl 713: 433-437 [CrossRef] [Google Scholar] [PubMed]
  13. Shin HS (2009) Determination of malondialdehyde in human blood by headspace-solid phase micro-extraction gas chromatographymass spectrometry after derivatization with 2,2,2-trifluoroethylhydrazine. J Chromatogr B Analyt Technol Biomed Life Sci 877: 3707-371 [CrossRef] [Google Scholar] [PubMed]
  14. Fitzmaurice PS, Tong J, Yazdanpanah M, Liu PP, Kalasinsky KS et al. (2006) Levels of 4-hydroxynonenal and malondialdehyde are increased in brain of human chronic users of methamphetamine. J Pharmacol Exp Ther 319: 703-709 [CrossRef] [Google Scholar] [PubMed]
  15. Requena JR, Fu MX, Ahmed MU, Jenkins AJ, Lyons TJ et al. (1997) Quantification of malondialdehyde and 4-hydroxynonenal adducts to lysine residues in native and oxidized human low-density lipoprotein. Biochem J 322: 317-325 [CrossRef] [Google Scholar] [PubMed]
  16. Sahin U, Unlu M, Ozgumer MF, Taahan V, Akkaya A, et al. (2001) Lipid peroxidation and erythrocyte superoxide dismutase activity in primary lung cancer. Biomed Res 12: 13-16 [CrossRef] [Google Scholar] [PubMed]
  17. Jeny C, Goy J, Fechner J, Loeper J, Emerit J, et al. (1986) Study of lipid peroxidation by the assay of malondialdehyde in human and experimental atheroma. Presse Med 15: 1131-1133 [Google Scholar] [PubMed]
  18. Kakorin ID, Antonova OA, Balashov SA, Mel'kumiantsAM (2010) Effect of malondialdehyde on deformability of human umbilical vein endothelial cells. Ross Fiziol Zh Im IM Sechenova 96: 147-153 [Google Scholar] [PubMed]
  19. Corbucci GG, Gasparetto A, Antonelli M, Bufi M, De Blasi RA, et al. (1986) Changes in the levels of coenzyme Q homologues, alphatocopherol and malondialdehyde in human tissue during the course of circulatory shock. Int J Tissue React 8: 421-430 [Google Scholar] [PubMed]
  20. Gwarzo MY, Muhammad SA (2010) Extracellular superoxide dismutase activity and plasma malondialdehyde in human immunodeficiency virus subjects of Kano state as surrogate markers of CD4 status. Int J Biomed Sci 6: 294- 300 [PubMed]
  21. Karademir CB, Ozden S, Alpertunga B (2007) Effects of trichlorfon on malondialdehyde and antioxidant system in human erythrocytes. Toxicol In Vitro 21: 1538-1544 [CrossRef] [Google Scholar] [PubMed]
  22. Akbulut H, Akbulut KG, Icli F, Buyukcelik A (2003) Daily variations of plasma malondialdehyde levels in patients with early breast cancer. Cancer Detect Prev 27: 122-126 [CrossRef] [Google Scholar] [PubMed]
  23. do Val Carneiro JL, Nixdorf SL, Mantovani MS, da Silva do Amaral Herrera AC, Aoki MN, et al. (2009) Plasma malondialdehyde levels and CXCR4 expression in peripheral blood cells of breast cancer patients. J Cancer Res Clin Oncol 135: 997-1004 [CrossRef] [Google Scholar] [PubMed]
  24. Macotpet A, Suksawat F, Sukon P, Pimpakdee K, Pattarapanwichien E, et al. (2013) Oxidative stress in cancer-bearing dogs assessed by measuring serum malondialdehyde. BMC. Vet Res 9: 101 [CrossRef] [Google Scholar] [PubMed]
  25. Fischer SG, Perez RS, Nouta J, Zuurmond WW, Scheffer PG, et al. (2013) Oxidative Stress in Complex Regional Pain Syndrome (CRPS): No Systemically Elevated Levels of Malondialdehyde, F2-Isoprostanes and 8OHdG in a Selected Sample of Patients. Int J Mol Sci 14: 7784-7794 [CrossRef] [Google Scholar] [PubMed]
  26. Fucile C, Marini V, Zuccoli ML, Leone S, Robbiano L, et al. (2013) HPLC determination of malondialdehyde as biomarker for oxidative stress: application in patients with alcohol dependence. Clin Lab 59: 837-841 [Google Scholar] [PubMed]
  27. Karakurt Arıtürk Ö, Üreten K, Sarı M, Yazıhan N, Ermiş E, et al. (2013) Relationship of paraoxonase-1, malondialdehyde and mean platelet volume with markers of atherosclerosis in familial Mediterranean fever: an observational study. Anadolu Kardiyol Derg 13: 357-362 [CrossRef] [Google Scholar] [PubMed]
  28. Matejckova J, Samec M, Samcova E, Rokyta R, Tuma P, et al. (2013) The effect of vitamin E on plasmatic malondialdehyde levels during surgical removal of ovarian and endometrial carcinomas. Eur J Gynaecol Oncol 34: 329-331 [Google Scholar] [PubMed]
  29. Nucci C, Di Pierro D, Varesi C, Ciuffoletti E, Russo R, et al. (2013) Increased malondialdehyde concentration and reduced total antioxidant capacity in aqueous humor and blood samples from patients with glaucoma. Mol Vis 19: 1841-1846 [Google Scholar] [PubMed]
  30. Antus B, Harnasi G, Drozdovszky O, Barta I (2014) Monitoring oxidative stress during chronic obstructive pulmonary disease exacerbations using malondialdehyde. Respirology,19: 74-79 [CrossRef] [Google Scholar] [PubMed]
  31. Schutt F, Bergmann M, Holz FG, Kopitz J (2003) Proteins modified by malondialdehyde, 4-hydroxynonenal, or advanced glycation end products in lipofuscin of human retinal pigment epithelium. Invest Ophthalmol Vis Sci, 44: 3663-3668 [CrossRef] [Google Scholar] [PubMed]
  32. Borchman D, Yappert MC, RubiniRQ, Paterson CA (1989) Distribution of phospholipid-malondialdehyde- adduct in the human lens. Curr Eye Res 8: 939-946 [Google Scholar] [PubMed]
  33. Yapicioğlu H, Satar M, Canacankatan N, Tutak E, Sertdemir Y, et al. (2006) The effect of human growth hormone on superoxide dismutase activity, glutathione and malondialdehyde levels of hypoxicischemic newborn rat brain. Biol Neonate 90: 168-173 [CrossRef] [Google Scholar] [PubMed]
  34. Lazzarino G, Tavazzi B, Di PD, Vagnozzi R, Penco M, et al. (1995) The relevance of malondialdehyde as a biochemical index of lipid peroxidation of postischemic tissues in the rat and human beings. Biol Trace Elem Res 47: 165-170 [CrossRef] [Google Scholar] [PubMed]
  35. Janssen M, Koster JF, Bos E, de Jong JW (1993) Malondialdehyde and glutathione production in isolated perfused human and rat hearts. Circ Res, 73: 681-688 [CrossRef] [Google Scholar] [PubMed]
  36. Das P, Choudhari AR, Singh AK, Singh R (2009) Correlation among routine semen parameters, sperm viabilty and malondialdehyde levels in human subjects with different fertility potential. Indian J Physiol Pharmacol 53: 253- 258 [Google Scholar] [PubMed]
  37. Gomez E, Irvine DS, Aitken RJ (1998) Evaluation of a spectrophotometric assay for the measurement of malondialdehyde and 4- hydroxyalkenals in human spermatozoa: relationships with semen quality and sperm function. Int J Androl 21: 81-94 [CrossRef] [PubMed]
  38. Armas-Padilla MC, Armas-Hernández MJ, Sosa-Canache B, Cammarata R, Pacheco B, et al. (2007) Nitric oxide and malondialdehyde in human hypertension. Am J Ther 14: 172-176 [CrossRef] [Google Scholar] [PubMed]
  39. Mohan KS, Venkataramana G (2007) Status of lipid peroxidation, Glutathione, ascorbic acid, vitamin E & antioxidant enzymes in patients with pregnancy induced hypertension. Indian J physiol Pharmacol 51: 284-88 [Google Scholar] [PubMed]
  40. EI-Bana SM, ei-Din AE, Isamil ZA (2001) Fetal and maternal oxidative stress in normal and abnormal pregnancies. Ain Shans Med J 52: 421-31
  41. Dreissigacker U, Suchy MT, Maassen N, Tsikas D (2010) Human plasma concentrations of malondialdehyde (MDA) and the F2-isoprostane 15(S)-8- iso-PGF (2alpha) may be markedly compromised by hemolysis: evidence by GC-MS/MS and potential analytical and biological ramifications. Clin Biochem 43: 159-167 [CrossRef] [Google Scholar] [PubMed]
  42. Tesoriere L, D'Arpa D, Butera D, Pintaudi AM, Allegra M et al. (2002) Exposure to malondialdehyde induces an early redox unbalance preceding membrane toxicity in human erythrocytes. Free Radic Res 36: 89-97 [CrossRef] [Google Scholar] [PubMed]
  43. Allegra M, Gentile C, Tesoriere L, Livrea MA (2002) Protective effect of melatonin against cytotoxic actions of malondialdehyde: an in vitro study on human erythrocytes. J Pineal Res 32: 187-193 [CrossRef] [Google Scholar] [PubMed]
  44. Ponicke K, Forster W (1984) Influence of leukotriene C4 on aggregation and on malondialdehyde formation of human blood platelets. Biomed Biochim Acta 43: S459-S462 [Google Scholar] [PubMed]
  45. Serarslan G, Yilmaz HR, Sogut S (2005) Serum antioxidant activities, malondialdehyde and nitric oxide levels in human cutaneous leishmaniasis. Clin Exp Dermatol 30: 267-271 [CrossRef] [Google Scholar] [PubMed]
  46. Verma SP, Philippot JR, Bonnet B, Sainte-Marie J, Moschetto Y, et al. (1985) Raman studies of structural rearrangements induced in human plasma lipoprotein carotenoids by malondialdehyde. Lipids 20: 890-896 [CrossRef] [Google Scholar] [PubMed]
  47. Kotani K, Maekawa M, Kanno T, Kondo A, Toda N, et al. (1994) Distribution of immunoreactive malondialdehyde- modified low-density lipoprotein in human serum. Biochim Biophys Acta 1215: 121- 125 [CrossRef] [Google Scholar] [PubMed]
  48. Lecomte E, Artur Y, Chancerelle Y, Herbeth B, Galteau MM, et al. (1993) Malondialdehyde adducts to, and fragmentation of, apolipoprotein B from human plasma. Clin Chim Acta 218: 39-46 [CrossRef] [Google Scholar] [PubMed]
  49. Salmon S, Mazière C, Auclair M, Theron L, Santus R, et al. (1992) Malondialdehyde modification and copperinduced auto-oxidation of high-density lipoprotein decrease cholesterol efflux from human cultured fibroblasts. Biochim Biophys Acta 1125: 230-235 [CrossRef] [Google Scholar] [PubMed]
  50. Yang RL, Shi YH, Hao G, Li W, Le GW, et al. (2008) Increasing Oxidative Stress with Progressive Hyperlipidemia in Human: Relation between Malondialdehyde and Atherogenic Index. J Clin Biochem Nutr 43: 154-158 [CrossRef] [Google Scholar] [PubMed]
  51. Wang H, Msarnett LJ, Harris TM, Rizzo CJ (2004) A novel synthesis of malondialdehyde adducts of deoxyguanosine, deoxyadenosine and deoxycytidine. Chem Res Toxicol, 17: 144-149 [CrossRef] [Google Scholar]
  52. Sharma RA, Gescher A, Plastaras JP, Leuratti C, Singh R, et al. (2001) Cyclooxygenase-2, malondialdehyde and pyrimidopurinone adducts of deoxyguanosine in human colon cells. Carcinogenesis 22: 1557-1560 [CrossRef] [Google Scholar] [PubMed]
  53. Maddukuri L, Eoff RL, Choi JY, Rizzo CJ, Guengerich FP, et al (2010) In vitro bypass of the major malondialdehyde-and base propenal-derived DNA adduct by human Y-family DNA polymerases kappa, iota, and Rev1. Biochemistry 49: 8415-8424 [CrossRef] [Google Scholar] [PubMed]
  54. Sun X, Nair J, Bartsch H (2004) A modified immuno-enriched 32P-postlabeling method for analyzing the malondialdehydedeoxyguanosine adduct, 3-(2-deoxy-beta-Derythro-pentofuranosyl) - pyrimido1, 2alpha.purin-10(3H)one in human tissue samples. Chem Res Toxicol, 17: 268-272 [CrossRef] [Google Scholar] [PubMed]
  55. Wang M, Dhingra K, Hittelman WN, Liehr JG, deA M, et al. (1996) Lipid peroxidationinduced putative malondialdehyde-DNA adducts in human breast tissues. Cancer Epidemiol Biomarkers Prev 5: 705-710 [Google Scholar] [PubMed]
  56. Rouzer CA, Chaudhary AK, Nokubo M, Ferguson DM, ReddyGR, et al. (1997) Analysis of the malondialdehyde-2'-deoxyguanosine adduct pyrimidopurinone in human leukocyte DNA by gas chromatography/ electron capture/negative chemical ionization/mass spectrometry. Chem Res Toxicol 10: 181-188 [CrossRef] [Google Scholar] [PubMed]
  57. Niedernhofer LJ, Daniels JS, Rouzer CA, Greene RE, Marnett LJ, et al. (2003) Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells. J Biol Chem 278: 31426-31433 [CrossRef] [Google Scholar] [PubMed]
  58. Wong SHY, Knight JA, Hopfer SH, Zaaharia O, Leach CN, et al. (1987) Lipoperoxides in plasma as measure by liquidchomatographic separation of malondialdehyde-thiobaarbituric acid adduct. Clin Chem 33: 214-220 [Google Scholar] [PubMed]
  59. Leuratti C, Singh R, Deag EJ, Griech E, Hughes R, et al. (1999) A sensitive immunoslot-blot assay for detection of malondialdehyde-deoxyguanosine in human DNA. IARC Sci Publ 197-203 [Google Scholar] [PubMed]
  60. Agarwal S, Wee JJ, Hadley M, Draper HH (1994) Identification of a deoxyguanosine-malondialdehyde adduct in rat and human urine. Lipids 29: 429-443 [CrossRef] [Google Scholar] [PubMed]
  61. Hadley M, Draper HH (1990) Isolation of a guanine-malondialdehyde adduct from rat and human urine. Lipids 25: 82-85 [CrossRef] [Google Scholar] [PubMed]
  62. Xing D, Song N, Tan W (2001) Detection of malondialdehyde-DNA adduct level by 32Ppostlabeling assay in normal human esophageal epithelium and esophageal squamous cell carcinoma. Zhonghua Zhong Liu Za Zhi 23: 473-476 [Google Scholar] [PubMed]
  63. Leuratti C, Watson MA, Deag EJ, Welch A, Singh R, et al. (2002) Detection of malondialdehyde DNA adducts in human colorectal mucosa: relationship with diet and the presence of adenomas. Cancer Epidemiol Biomarkers Prev 11: 267-273 [Google Scholar] [PubMed]
  64. Singh Z, Karthigesu IP, Singh P, Kaur R (2014) A Review: Use of Malondialdehyde as a Biomarker for Assessing Oxidative Stress in Different Disease Pathologies. Iranian J Publ Health 43: 7-16 [Google Scholar]
  65. Bruce W Halstead, “Methods for testing oxidative stress”
  66. Draper HH, Polensek L, Hadley M, McGirr LG (1984) Urinary malondialdehyde as an indicator of lipid peroxidation in the diet and in the tissues. Lipids 19: 836-843 [CrossRef] [Google Scholar] [PubMed]
  67. Brown ED, Morris VC, Rhodes DG, Sinha R, Levander OA, et al. (1995) Urinary malondialdehyde-equivalents during ingestion of meat cooked at high or low temperatures. Lipids 30: 1053-1056 [CrossRef] [Google Scholar] [PubMed]
  68. Sram RJ, Farmer P, Singh R, Garte S, Kalina I, et al. (2009) Effect of vitamin levels on biomarkers of exposure and oxidative damage-the EXPAH study. Mutat Res 672: 129-134 [CrossRef] [Google Scholar] [PubMed]