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International Journal of Pharmaceutical Sciences Research Volume 3 (2016), Article ID 3:IJPSR-117, 6 pages
http://dx.doi.org/10.15344/2394-1502/2016/117
Research Article
Medication Adherence, Persistence and Cost in Multiple Sclerosis Patients: Oral vs Parenteral Treatment

Fiorenzo Santoleri*, Ruggero Lasala, Andrea Logreco, Magda El Hassani and Alberto Costantini

Department of Pharmacy, AUSL Pescara, Via Renato Paolini 47, 65124 Pescara, Italy
Dr. Fiorenzo Santoleri, Department of Pharmacy, AUSL Pescara, Via Renato Paolini 47, 65124 Pescara, Italy, Tel: 393493635174; E-mail: fiorenzosantoleri@hotmail.com
27 August 2016; 10 December 2016; 12 December 2016
Santoleri F, Lasala R, Logreco A, Hassani ME, Costantini A, et al. (2016) Medication Adherence, Persistence and Cost in Multiple Sclerosis Patients. Oral vs Parenteral Treatment. Int J Pharma Sci Res 3: 117. doi: https://doi. org/10.15344/2394-1502/2016/117

References

  1. Tullman MJ (2013) Overview of the epidemiology, diagnosis, and disease progression associated with multiple sclerosis. Am J Manag Care 19: S15- 20. View
  2. Dutta R, Trapp BD (2014) Relapsing and progressive forms of multiple sclerosis: insights from pathology. Curr Opin Neurol 27: 271-278. View
  3. Leray E, Moreau T, Fromont A, Edan G (2015) Epidemiology of multiple sclerosis. Rev Neurol (Paris). 172: 3-13. View
  4. Loma I, Heyman R (2011) Multiple sclerosis: pathogenesis and treatment. Curr Neuropharmacol 9: 409-416. View
  5. Compston A, Coles A (2008) Multiple sclerosis. Lancet 372: 1502-1517. View
  6. Milo R, Miller A (2014) Revised diagnostic criteria of multiple sclerosis. Autoimmun Rev 13: 518-524. View
  7. Martinelli Boneschi F, Vacchi L, Rovaris M, Capra R, Comi G, et al. (2013) Mitoxantrone for multiple sclerosis. Cochrane Database Syst Rev 4: CD002127. View
  8. Kappos L, Polman CH, Freedman MS, Edan G, Hartung HP, et al. (2006) Treatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes. Neurology 67: 1242-1249. View
  9. [No authors listed] (1998) PRISMS Study Group Randomized doubleblind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. Lancet 352: 1498-1504. View
  10. Jacobs LD, Cookfair DL, Rudick RA, Herndon RM, Richert JR, et al. (1996) Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG). Ann Neurol 39: 285-294. View
  11. Ge Y, Grossman RI, Udupa JK, Fulton J, Constantinescu CS, et al. (2000) Glatiramer acetate (Copaxone) treatment in relapsing-remitting MS: quantitative MR assessment. Neurology 54: 813-817. View
  12. Bains SN, Hsieh FH, Rensel MR, Radojicic C, Katz HT, et al. (2010) Glatiramer acetate: successful desensitization for treatment of multiple sclerosis. Ann Allergy Asthma Immunol 104: 321-325. View
  13. Kappos L, Radue EW, O'Connor P, Polman C, Hohlfeld R, et al. (2010) A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med362: 387-401. View
  14. Cohen JA, Chun J (2011) Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis. Ann Neurol 69: 759-777. View
  15. Gajofatto A, Turatti M, Monaco S, Benedetti MD (2015) Clinical efficacy, safety, andtolerability of fingolimod for the treatment of relapsing-remitting multiplesclerosis. Drug Healthc Patient Saf 7: 157-167. View
  16. O'Connor PW, Li D, Freedman MS, Bar-Or A, Rice GP, et al. (2006) A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses. Neurology 66: 894-900. View
  17. O'Connor P, Wolinsky JS, Confavreux C, Comi G, Kappos L, et al. (2011) Randomized trial of oral teriflunomide for relapsing multiple sclerosis. N Engl J Med 365: 1293-1303. View
  18. He D, Xu Z, Dong S, Zhang H, Zhou H, et al. (2012) Teriflunomide for multiple sclerosis. Cochrane Database Syst Rev 12: CD009882. View
  19. Kappos L, Gold R, Miller DH, Macmanus DG, Havrdova E, et al. (2008) Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebocontrolled phase IIb study. Lancet 372:1463-1472. View
  20. Shirani A, Okuda DT, Stüve O3,4 (2016) Therapeutic Advances and Future Prospects in Progressive Forms of Multiple Sclerosis. Neurotherapeutics 13: 58-69. View
  21. Tolley K, Hutchinson M, You X, Wang P, Sperling B, et al. (2015) A Network Meta-Analysis of Efficacy and Evaluation of Safety of Subcutaneous Pegylated Interferon Beta-1a versus Other Injectable Therapies for the Treatment of Relapsing-Remitting Multiple Sclerosis. PLoS One 10: e0127960. View
  22. Klauer T, Zettl UK (2008) Compliance, adherence, and the treatment of multiple sclerosis. J Neurol 255 Suppl 6: 87-92. View
  23. Hutchinson M (2005) Treatment adherence: what is the best that can be achieved? Int MS J 12: 73. View
  24. Devonshire V, Lapierre Y, Macdonell R, Ramo-Tello C, Patti F, et al. (2011) The Global Adherence Project (GAP): a multicenter observational study on adherence to disease-modifying therapies in patients with relapsingremitting multiple sclerosis. Eur J Neurol 18: 69-77. View
  25. Río J, Porcel J, Téllez N, Sánchez-Betancourt A, Tintoré M, et al. (2005) Factors related with treatment adherence to interferon beta and glatiramer acetate therapy in multiple sclerosis. Mult Scler 11: 306-309. View
  26. Río J, Porcel J, Téllez N, Sánchez-Betancourt A, Tintoré M, et al. (2005) Factors related with treatment adherence to interferon beta and glatiramer acetate therapy in multiple sclerosis. Mult Scler 11: 306-309. View
  27. Girouard N, Soucy N (2011) Patient considerations in the management of multiple sclerosis: development and clinical utility of oral agents. Patient Prefer Adherence 5: 101-108. View
  28. World Health Organization (2010) Adherence to long-term therapies: Evidence for action. View
  29. Treadaway K, Cutter G, Salter A, Lynch S, Simsarian J, et al. (2009) Factors that influence adherence with disease-modifying therapy in MS. J Neurol 256: 568-576. View
  30. Tremlett HL, Oger J (2003) Interrupted therapy: stopping and switching of the beta-interferons prescribed for MS. Neurology 61: 551-554. View
  31. O'Rourke KE, Hutchinson M (2005) Stopping beta-interferon therapy in multiple sclerosis: an analysis of stopping patterns. Mult Scler 11: 46-50. View
  32. Río J, Porcel J, Téllez N, Sánchez-Betancourt A, Tintoré M, et al. (2005) Factors related with treatment adherence to interferon beta and glatiramer acetate therapy in multiple sclerosis. Mult Scler 11: 306-309. View
  33. Portaccio E, Zipoli V, Siracusa G, Sorbi S, Amato MP (2008) Long-term adherence to interferon beta therapy in relapsing-remitting multiple sclerosis. Eur Neurol 59: 131-135. View
  34. Hupperts R, Becker V, Friedrich J, Gobbi C, Salgado AV, et al. (2015) Multiple sclerosis patients treated with intramuscular IFN-ß-1a autoinjector in areal-world setting: prospective evaluation of treatment persistence, adherence, quality of life and satisfaction. Expert Opin Drug Deliv 12: 15- 25. View
  35. Katsarava Z, Ehlken B, Limmroth V, Taipale K, et al. (2015) Adherence and cost in multiple sclerosis patients treated with IM IFN beta-1a: impact of the CARE patient management program. BMC Neurol 15: 170. View
  36. Kozma CM, Phillips AL, Meletiche DM (2014) Use of an early diseasemodifying drug adherence measure to predict future adherence in patients with multiple sclerosis. J Manag Care Spec Pharm 20: 800-807. View
  37. Evans C, Marrie RA, Zhu F, Leung S, Lu X, et al. (2016) Adherence and persistence to drug therapies for multiple sclerosis: A population-based study. Mult Scler Relat Disord 8: 78-85. View
  38. Santoleri F, Sorice P, Lasala R, Rizzo RC, Costantini A (2013) Patient adherence and persistence with Imatinib, Nilotinib, Dasatinib in clinical practice. PLoS One 8: e56813. View
  39. Deambrosis P, Saramin C, Terrazzani G, Scaldaferri L, Debetto P, et al. (2007) Evaluation of the prescription and utilization patterns of statins in an Italian local health unit during the period 1994-2003. Eur J Clin Pharmacol 63: 197-203. View
  40. Roggeri D, Saramin C, Terrazzani G, Zusso M, Giusti P, et al. (2007) Resource consumption and costs of treating pain in patients affected by cancer in a district of northeast Italy. Pharmacol Res 56: 329-334. View
  41. Gagliotti C, Ricchizzi E, Buttazzi R, Tumietto F, Resi D, et al. (2014) Hospital statistics for antibiotics: defined versus prescribed daily dose. Infection 42: 869-873. View
  42. Grimmsmann T, Himmel W (2011) Discrepancies between prescribed and defined daily doses: a matter of patients or drug classes? Eur J Clin Pharmacol 67: 847-854. View
  43. Río J, Tintoré M, Sastre-Garriga J, Nos C, Castilló J, et al. (2012) Change in the clinical activity of multiple sclerosis after treatment switch for suboptimal response. Eur J Neurol 19: 899-904. View
  44. Giovannoni G, Southam E, Waubant E (2012) Systematic review of disease-modifying therapies to assess unmet needs in multiple sclerosis: tolerability and adherence. Mult Scler 18: 932-946. View
  45. Singer BA (2013) Initiating oral fingolimod treatment in patients with multiple sclerosis. Ther Adv Neurol Disord 6: 269-275. View
  46. Bergvall N, Makin C, Lahoz R, Agashivala N, Pradhan A, et al. (2014) Relapse rates in patients with multiple sclerosis switching from interferon to fingolimod or glatiramer acetate: a US claims database study. PLoS One 9: e88472. View
  47. Gasperini C, Cefaro LA, Borriello G, Tosto G, Prosperini L, et al. (2008) Emerging oral drugs for multiple sclerosis. Expert Opin Emerg Drugs 13: 465-477. View
  48. Cramer JA, Roy A, Burrell A, Fairchild CJ, Fuldeore MJ, et al. (2008) Medication compliance and persistence: terminology and definitions. Value Health 11: 44-47. View
  49. Sinnott SJ, Polinski JM, Byrne S, Gagne JJ (2016) Measuring drug exposure: concordance between defined daily dose and days' supply depended on drug class. J Clin Epidemiol 69: 107-113. View
  50. WHO Collaborating Centre for Drug Statistics Methodology (2015) Guidelines for ATC classification and DDD assignment 2015, Oslo.
  51. Agashivala N, Wu N, Abouzaid S, Wu Y, Kim E, et al. (2013) Compliance to fingolimod and other disease modifying treatments in multiple sclerosis patients, a retrospective cohort study. BMC Neurol 13: 138. View
  52. Fernández O, Arroyo R, Martínez-Yélamos S, Marco M, Merino JA, et al. (2016) Long-Term Adherence to IFN Beta-1a Treatment when Using RebiSmart® Device inPatients with Relapsing-Remitting Multiple Sclerosis. PLoS One 11: e0160313. View
  53. Markowitz CE (2015) Switching therapies in MS: what are the options? J Clin Psychiatry 76: e6. View
  54. Singer BA (2013) Initiating oral fingolimod treatment in patients with multiple sclerosis. Ther Adv Neurol Disord 6: 269-275. View
  55. Meng X, Chin PS, Hashmonay R, Zahur Islam M, Cutter G (2015) Effect of switching from intramuscular interferon ß-1a to oral fingolimod on time to relapse in patients with relapsing-remitting multiple sclerosis enrolled in a 1-year extension of TRANSFORMS. Contemp Clin Trials 41: 69-74. View