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How to Cite | Author Information | Publication History | Funding Information
International Journal of Nursing & Clinical Practices Volume 3 (2016), Article ID 3:IJNCP-174, 5 pages
http://dx.doi.org/10.15344/2394-4978/2016/174
Research Article
Gene Therapy for Peripheral Arterial Disease and Nursing Implications: Clinical Experience on the use of Sendai Viral Vector

Michiko Tanaka* and Yoshikazu Yonemitsu

R & D Laboratory for Innovative Biotherapeutics Science, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
Dr. Michiko Tanakaa, R & D Laboratory for Innovative Biotherapeutics Science, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan; E-mail: tmiciko@med.kyushu-u.ac.jp
04 January 2016; 02 March 2016; 04 March 2016
Tanaka M, Yonemitsu Y (2016) Gene Therapy for Peripheral Arterial Disease and Nursing Implications: Clinical Experience on the use of Sendai Viral Vector. Int J Nurs Clin Pract 3: 174. doi: http://dx.doi.org/10.15344/2394-4978/2016/174
This study was supported by the Health and Labor Sciences Research Grant, and partially supported by the Japan Agency for Medical Research and development, AMED.
© 2016 Tanaka et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

References

  1. Scott K, White K, Johnson C, Roydhouse J K (2012) Knowledge and skills of cancer clinical trials nurses in Australia. J Adv Nurs 68: 1111-1121 [CrossRef] [Google Scholar] [PubMed]
  2. Liu K (2003) Breakthroughs in cancer gene therapy. Semin Oncol Nurs 19: 217-226 [Google Scholar] [PubMed]
  3. Smith K (2003) Gene therapy: theoretical and bioethical concepts. Arch Med Res 34: 247-268 [CrossRef] [Google Scholar] [PubMed]
  4. Mughal NA, Russell DA, Ponnambalam S, Homer-Vanniasinkam S (2012) Gene therapy in the treatment of peripheral arterial disease. Br J Surg 99: 6-15 [CrossRef] [Google Scholar] [PubMed]
  5. Madonna R, Rokosh G (2012) Insights into gene therapy for critical limb ischemia: the devil is in the details. Vascul Pharmacol 57: 10-14 [CrossRef] [Google Scholar] [PubMed]
  6. Tiong A, Freedman SB (2004) Gene therapy for cardiovascular disease: the potential of VEGF. Curr Opin Mol Ther 6: 151-159 [Google Scholar] [PubMed]
  7. Takeshita S, Zheng LP, Brogi E, Keamey M, Pu LQ, et al. (1994) Therapeutic angiogenesis: a single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model. J Clin Invest 93: 662-670 [CrossRef] [Google Scholar] [PubMed]
  8. Sedighiani F, Nikol S (2011) Gene therapy in vascular disease. Surgeon 9: 326-335 [CrossRef] [Google Scholar] [PubMed]
  9. Davies MG (2012) Critical limb ischemia: cell and molecular therapies for limb salvage. Methodist Debakey Cardiovasc J 8: 20-27 [Google Scholar] [PubMed]
  10. Berger JS, Hiatt WR (2012) Medical therapy in peripheral artery disease. Circulation 126: 491-500 [CrossRef] [Google Scholar] [PubMed]
  11. Germani A, Di Campli C, Pompilio G, Biglioli P, Capogrossi MC (2009) Regenerative therapy in peripheral artery disease. Cardiovasc Ther 27: 289-304 [CrossRef] [Google Scholar] [PubMed]
  12. Baumgartner I, Pieczek A, Manor O, Blair R, Kearney M, et al. (1998). Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia. Circ 97: 1114-1123 [CrossRef] [Google Scholar] [PubMed]
  13. Grochot-Przeczek A1, Dulak J, Jozkowicz A (2013) Therapeutic angiogenesis for revascularization in peripheral artery disease. Gene 525: 220-228. [CrossRef] [Google Scholar] [PubMed]
  14. Isner JM, Pieczek A, Schainfeld R, Blair R, Haley L, et al. (1996) Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb. Lancet 348: 370-374 [CrossRef] [Google Scholar] [PubMed]
  15. Bartel RL, Booth E, Cramer C, Ledford K, Watling S, et al. (2013) From bench to bedside: review of gene and cell-based therapies and the slow advancement into phase 3 clinical trials, with a focus on Aastrom's Ixmyelocel-T. Stem Cell Rev 9: 373-383 [CrossRef] [Google Scholar] [PubMed]
  16. Gene Therapy Clinical Trials Worldwide [View]
  17. Davies MG (2012) Critical limb ischemia: cell and molecular therapies for limb salvage. Methodist Debakey Cardiovasc J 8: 20-27 [Google Scholar] [PubMed]
  18. De Haro J, Acin F, Lopez-Quintana A, Florez A, Martinez-Aguilar E, et al. (2009) Meta-analysis of randomized, controlled clinical trials in angiogenesis: gene and cell therapy in peripheral arterial disease. Heart Vessels 24: 321-328 [CrossRef] [Google Scholar] [PubMed]
  19. Witzenbichler B, Mahfoudi A, Soubrier F, Le Roux A, Branellec D, et al. (2006) Intramuscular gene transfer of fibroblast growth factor-1 using improved pCOR plasmid design stimulates collateral formation in a rabbit ischemic hindlimb model. J Mol Med 84: 491-502 [CrossRef] [Google Scholar] [PubMed]
  20. Yonemitsu Y, Kitson C, Ferrari S, Farley R, Griesenbach U, et al. (2000) Efficient gene transfer to airway epithelium using recombinant Sendai virus. Nature Biotechnol 18: 970-973 [CrossRef] [Google Scholar] [PubMed]
  21. Tabata H, Silver M, Isner JM (1997) Arterial gene transfer of acidic fibroblast growth factor for therapeutic angiogenesis in vivo: critical role of secretion signal in use of naked DNA. Cardiovasc Res 35: 470-479 [CrossRef] [Google Scholar] [PubMed]
  22. Presta M, Dell'Era P, Mitola S, Moroni E, Ronca R, et al. (2005) Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis. Cytokine Growth Factor Rev 16: 159-178 [CrossRef] [Google Scholar] [PubMed]
  23. Onimaru M, Yonemitsu Y, Fujii T, Tanii M, Nakano T, et al. (2009) VEGF-C regulates lymphangiogenesis and capillary stability by regulation of PDGF-B. Am J Physiol Heart Circ Physiol 297: H1685-1696 [CrossRef] [Google Scholar] [PubMed]
  24. Fujii T, Yonemitsu Y, Onimaru M,Tanii M, Nakano T, et al. (2006) Nonendothelialmesenchymal cell-derived MCP-1 is required for FGF-2- mediated therapeutic neovascularization: critical role of the inflammatory/ arteriogenic pathway. Arterioscler Thromb Vasc Biol 26: 2483-2489 [CrossRef] [Google Scholar]
  25. Tsutsumi N, Yonemitsu Y, Shikada Y, Onimaru M, Tanii M, et al. (2004) Essential role of PDGFRa-p70S6K signaling in mesenchymal cells during therapeutic and tumor angiogenesis in vivo: role of PDGFRa during angiogenesis. Circulation Res 94: 1186-1194 [CrossRef] [Google Scholar] [PubMed]
  26. Layman H, Rahnemai-Azar AA, Pham SM, Tsechpenakis G, Andreopoulos FM (2011) Synergistic angiogenic effect of codelivering fibroblast growth factor 2 and granulocyte-colony stimulating factor from fibrin scaffolds and bone marrow transplantation in critical limb ischemia. Tissue Eng Part A 17: 243-254 [CrossRef] [Google Scholar] [PubMed]
  27. Shoji T, Yonemitsu Y, Komori K,Tanii M, Itoh H, et al. (2003) Intramuscular gene transfer of FGF-2 attenuates endothelial dysfunction and inhibits intimal hyperplasia of vein grafts in poor-runoff limbs of rabbit. Am J Physiol Heart CircPhysiol, 285, H173-H182 [CrossRef] [Google Scholar] [PubMed]
  28. Onimaru M, Yonemitsu Y, Tanii M, Nakagawa K, Masaki I, et al. (2002) Fibroblast growth factor-2 gene transfer can stimulate hepatocyte growth factor expression irrespective of hypoxia-mediated downregulation in ischemic limbs. Circ Res 91: 923-930 [CrossRef] [Google Scholar] [PubMed]
  29. Masaki I, Yonemitsu Y, Yamashita A, Sata S, Tanii M, (2002) Angiogenic gene therapy for experimental critical limb ischemia: acceleration of limb loss by overexpression of vascular endothelial growth factor 165 but not of fibroblast growth factor-2. Circulation Res 90: 966-973 [CrossRef] [Google Scholar] [PubMed]
  30. Iida A, Hasegawa M (2002) Cytoplasmic RNA vector derived from nontransmissible Sendai virus. Production and use. Methods Mol Med 69: 361-370 [Google Scholar] [PubMed]
  31. Inoue M, Tokusumi Y, Ban H, Shirakawa M, Kanaya T, et al. (2004). Recombinant Sendai virus vectors deleted in both the matrix and the fusion genes: efficient gene transfer with preferable properties. J Gene Med 6: 1069-1081 [CrossRef] [Google Scholar] [PubMed]
  32. Baumgartner I (2001) Lessons learned from human gene therapy in patients with chronic critical limb ischemia. J Invasive Cardiol 13: 330-332 [Google Scholar] [PubMed]
  33. Bitzer M, Ungerechts G, Bossow S, Graepler F, Sedlmeier R, et al. (2003). Negative-strand RNA viral vectors: intravenous application of Sendai virus vectors for the systemic delivery of therapeutic genes. Mol Ther, 7: 210- 217 [CrossRef] [Google Scholar] [PubMed]
  34. Yonemitsu Y, Matsumoto T, Itoh H, Okazaki J, Uchiyama M, et al. (2013). DVC1-0101 to treat peripheral arterial disease: a phase I/IIa open-label dose-escalation clinical trial. Mol Ther 21: 707-714 [CrossRef] [Google Scholar] [PubMed]
  35. Robinson KD, Abernathy E, Conrad KJ (1996) Gene therapy of cancer. Semin Oncol Nurs 12: 142-151 [PubMed]
  36. Anderson G (2008) Ethical preparedness and performance of gene therapy study co-ordinators. Nurs Ethics 15: 208-221 [CrossRef] [Google Scholar] [PubMed]
  37. Postin RD, Buescher CR (2010) The essential role of the clinical research nurse. Urol Nurs 30: 55-77 [Google Scholar] [PubMed]
  38. Liu ZM, Liu C, Li JY, Yu CH, Jiang Y (2011) The attitude of oncology physicians and nurses to the acceptance of new drugs for gene therapy. J Cancer Educ 26: 248-253 [CrossRef] [Google Scholar] [PubMed]
  39. Rieger PT (2001) The role of oncology nurses in gene therapy. Lancet Oncol 2: 233-238 [CrossRef] [Google Scholar] [PubMed]
  40. Hull D, Chester M (2002) Gene therapy trials: a patient pathway. Nurs Stand 17: 39-42 [PubMed]
  41. Hedman M, Muona K, Hedman A, Kivelä A, Syvänne M, et al. (2009) Eight-year safety follow-up of coronary artery disease patients after local intracoronary VEGF gene transfer. Gene Ther 16: 629-634 [CrossRef] [Google Scholar] [PubMed]
  42. Johnson S, Stevenson K (2010) Nursing research or research nursing? Two separate terms, two separate care. Nurse Res 17: 32-40 [CrossRef] [Google Scholar] [PubMed]
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