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International Journal of Physical Therapy & Rehabilitation Volume 3 (2017), Article ID 3:IJPTR-138, 9 pages
https://doi.org/10.15344/2455-7498/2017/138
Research Article
Special Issue: Various Approaches for Rehabilitation Science
Exercise-induced Release of Cytokines/Myokines in a Single Exercise Test before and after a Training Intervention in Patients with Mild Cognitive Impairment

Marie E. Bengtsson-Lindberg1, Lotta Wilke2, Susanna Vestberg3, Helene Jacobsson4 and Anita Wisén5*

1Clinical Memory Researh Unit, Dept. of Clinical Sciences, Malmö, Lund University, Sweden
2Biomedical analyst,Laboratory Medicine, Skåne University Hospital, Clinical Immunology and Transfusion Medicine, Division of immunology, Lund, Sweden
3Department of Psychology, Lund University, Sweden
4Unit for Medical Statistics and Epidemiology, Clinical Studies Sweden – Forum South, Skåne University Hospital, Lund, Sweden
5Physiotherapy research group, Department of Health Sciences, Lund University, Sweden
Dr. Anita Wisén, Physiotherapy research group, Department of Health Sciences, Lund University, Sweden, Tel: +46 76 580 15 14; E-mail: anita.wisen@med.lu.se
22 August 2017; 02 October 2017; 04 October 2017
Bengtsson-Lindberg ME, Wilke L, Vestberg S, Jacobsson H, Wisén A (2017) Exercise-induced Release of Cytokines/Myokines in a Single Exercise Test before and after a Training Intervention in Patients with Mild Cognitive Impairment. Int J Phys Ther Rehab 3: 138. doi: https://doi.org/10.15344/2455-7498/2017/138
This study was supported by Ribbingska memory-foundation,Greta and Johan Kocks foundations, Region Skåne and the Memory Clinic at Skåne University Hospital, Lund, Sweden.
© 2017 Bengtsson-Lindberg et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

References

  1. Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund LO, et al. (2004) Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med 256: 240-246 [CrossRef] [Google Scholar] [PubMed]
  2. Bruscoli M, Lovestone S (2004) Is MCI really just early dementia? A systematic review of conversion studies. Int Psychogeriatr 16: 129-140 [CrossRef] [Google Scholar] [PubMed]
  3. Norton S, Matthews FE, Barnes DE, Yaffe K, Brayne C (2014) Potential for primary prevention of Alzheimer's disease: an analysis of population-based data. Lancet Neurol 13: 788-794 [CrossRef] [Google Scholar] [PubMed]
  4. Rovio S, Kareholt I, Helkala EL, Viitanen M, Winblad B, Tuomilehto J, et al. (2005) Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease. Lancet Neurol 4: 705-711 [CrossRef] [Google Scholar] [PubMed]
  5. Ngandu T, Lehtisalo J, Solomon A, Levalahti E, Ahtiluoto S, Antikainen R, et al. (2015) A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet 385: 2255-2263 [CrossRef] [Google Scholar] [PubMed]
  6. Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, et al. (2000) Inflammation and Alzheimer's disease. Neurobiology of aging 21: 383-421 [CrossRef] [Google Scholar] [PubMed]
  7. Furney SJ, Kronenberg D, Simmons A, Guntert A, Dobson RJ, Proitsi P, et al. (2011) Combinatorial markers of mild cognitive impairment conversion to Alzheimer's disease--cytokines and MRI measures together predict disease progression. J Alzheimers Dis 26 Suppl 3: 395-405 [CrossRef] [Google Scholar] [PubMed]
  8. Bermejo P, Martin-Aragon S, Benedi J, Susin C, Felici E, Gil P, et al. (2008) Differences of peripheral inflammatory markers between mild cognitive impairment and Alzheimer's disease. Immunol lett 117: 198-202 [CrossRef] [Google Scholar] [PubMed]
  9. Magaki S, Mueller C, Dickson C, Kirsch W (2007) Increased production of inflammatory cytokines in mild cognitive impairment. Exp Gerontol 42: 233-240 [CrossRef] [Google Scholar] [PubMed]
  10. Berk M, Wadee AA, Kuschke RH, O'Neill-Kerr A (1997) Acute phase proteins in major depression. J Psychosom Res 43: 529-534 [CrossRef] [Google Scholar] [PubMed]
  11. Dantzer R, Capuron L (2017) Inflammation-Associated Depression: Evidence, Mechanism and Implications. Geyer MA, Ellenbroek BA, Marsden CA, T.R.E. B, editors: Springer International Publishing AG
  12. Thomas AJ, Davis S, Morris C, Jackson E, Harrison R, O'Brien JT (2005) Increase in interleukin-1beta in late-life depression. Am J Psychiatry 162: 175-177 [CrossRef] [PubMed]
  13. Hestad KA, Tonseth S, Stoen CD, Ueland T, Aukrust P (2003) Raised plasma levels of tumor necrosis factor alpha in patients with depression: normalization during electroconvulsive therapy. J ECT 19: 183-188 [CrossRef] [Google Scholar] [PubMed]
  14. Lindqvist D, Janelidze S, Hagell P, Erhardt S, Samuelsson M, Minthon L, et al. (2009) Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity. Biol Psychiatry 66: 287-292 [CrossRef] [Google Scholar] [PubMed]
  15. Pedersen BK (2009) The diseasome of physical inactivity--and the role of myokines in muscle--fat cross talk. J Physiol 587: 5559-5568 [CrossRef] [Google Scholar] [PubMed]
  16. Sakurai T, Ogasawara J, Shirato K, Izawa T, Oh-Ishi S, Ishibashi Y, et al. (2017) Exercise Training Attenuates the Dysregulated Expression of Adipokines and Oxidative Stress in White Adipose Tissue. Oxid Med Cell Longev 2017: 9410954 [CrossRef] [Google Scholar] [PubMed]
  17. Fischer CP, Berntsen A, Perstrup LB, Eskildsen P, Pedersen BK (2007) Plasma levels of interleukin-6 and C-reactive protein are associated with physical inactivity independent of obesity. Scand J Med Sci Sports. 17: 580-587 [CrossRef] [Google Scholar] [PubMed]
  18. Henriksson J, Sundberg CJ (2015) General effects of physical activity, In: Physical Activity in the Prevention and Treatment of Disease, FYSS 2015
  19. Pedersen BK, Akerstrom TC, Nielsen AR, Fischer CP (2007) Role of myokines in exercise and metabolism. J Appl Physiol(1985) 103: 1093- 1098 [CrossRef] [Google Scholar] [PubMed]
  20. Professional Association for Physical Activity S (2015) Physical Activity in the Prevention and Treatment of Diseases, Professional Association for Physical Activity, Sweden
  21. Dunstan DW, Salmon J, Owen N, Armstrong T, Zimmet PZ, Welborn TA, et al. (2005) Associations of TV viewing and physical activity with the metabolic syndrome in Australian adults. Diabetologia 48: 2254-2261 [CrossRef] [Google Scholar] [PubMed]
  22. Simpson RJ, Kunz H, Agha N, Graff R (2015) Exercise and the Regulation of Immune Functions. Prog Mol Biol Transl Sci 135: 355-380 [CrossRef] [Google Scholar] [PubMed]
  23. Exercise for depression (2013) Cochrane Database of Systematic Reviews
  24. Erickson KI, Prakash RS, Voss MW, Chaddock L, Hu L, Morris KS, et al. (2009) Aerobic fitness is associated with hippocampal volume in elderly humans. Hippocampus 19: 1030-1039 [CrossRef] [Google Scholar] [PubMed]
  25. Mathur N, Pedersen BK (2008) Exercise as a mean to control low-grade systemic inflammation. Mediators Inflamm 2008: 109502 [CrossRef] [Google Scholar] [PubMed]
  26. Kivipelto M, Ngandu T, Laatikainen T, Winblad B, Soininen H, Tuomilehto J (2006) Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study. Lancet Neurol 5: 735-741 [CrossRef] [Google Scholar] [PubMed]
  27. Zheng G, Xia R, Zhou W, Tao J, Chen L (2016) Aerobic exercise ameliorates cognitive function in older adults with mild cognitive impairment: a systematic review and meta-analysis of randomised controlled trials. Br J Sports Med [CrossRef] [Google Scholar] [PubMed]
  28. Strohle A, Schmidt DK, Schultz F, Fricke N, Staden T, Hellweg R, et al. (2015) Drug and Exercise Treatment of Alzheimer Disease and Mild Cognitive Impairment: A Systematic Review and Meta-Analysis of Effects on Cognition in Randomized Controlled Trials. Am J Geriatr Psychiatry 23: 1234-1249 [CrossRef] [Google Scholar] [PubMed]
  29. Fiatarone Singh MA, Gates N, Saigal N, Wilson GC, Meiklejohn J, Brodaty H, et al. (2014) The Study of Mental and Resistance Training (SMART) study-resistance training and/or cognitive training in mild cognitive impairment: a randomized, double-blind, double-sham controlled trial. J Am Med Dir Assoc 15: 873-880 [CrossRef] [Google Scholar] [PubMed]
  30. Jensen CS, Hasselbalch SG, Waldemar G, Simonsen AH (2015) Biochemical Markers of Physical Exercise on Mild Cognitive Impairment and Dementia: Systematic Review and Perspectives. Front Neurol 6: 187 [CrossRef] [Google Scholar] [PubMed]
  31. Milanovic Z, Sporis G, Weston M (2015) Effectiveness of High-Intensity Interval Training (HIT) and Continuous Endurance Training for VO2max Improvements: A Systematic Review and Meta-Analysis of Controlled Trials. Sports Med 45: 1469-1481 [CrossRef] [Google Scholar] [PubMed]
  32. Pedersen BK (2011) Muscles and their myokines. J Exp Biol 214: 337-346 [CrossRef] [Google Scholar] [PubMed]
  33. Pedersen BK (2012) Muscular interleukin-6 and its role as an energy sensor. Med Sci Sports Exerc 44: 392-396 [CrossRef] [Google Scholar] [PubMed]
  34. Steensberg A, van Hall G, Osada T, Sacchetti M, Saltin B, Klarlund Pedersen B (2000) Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J Physiol 1: 237-242 [CrossRef] [Google Scholar] [PubMed]
  35. Pedersen BK, Febbraio MA (2012) Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol 8: 457-465 [CrossRef] [Google Scholar] [PubMed]
  36. Pedersen BK, Febbraio MA (2008) Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiolrev 88: 1379-1406 [CrossRef] [Google Scholar] [PubMed]
  37. Carey AL, Steinberg GR, Macaulay SL, Thomas WG, Holmes AG, Ramm G, et al. (2006) Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMPactivated protein kinase. Diabetes 55: 2688-2697 [CrossRef] [Google Scholar] [PubMed]
  38. Schnyder S, Handschin C (2015) Skeletal muscle as an endocrine organ: PGC-1alpha, myokines and exercise. Bone 80: 115-125 [CrossRef] [Google Scholar] [PubMed]
  39. Petersen AM, Pedersen BK (2006) The role of IL-6 in mediating the antiinflammatory effects of exercise. J Physiol Pharmacol 57 Suppl 10: 43-51 [Google Scholar] [PubMed]
  40. Allen J, Sun Y, Woods JA (2015) Exercise and the Regulation of Inflammatory Responses. Prog Mol Biol Transl Sci 135: 337-354 [CrossRef] [Google Scholar] [PubMed]
  41. Nimmo MA, Leggate M, Viana JL, King JA (2013) The effect of physical activity on mediators of inflammation. Diabetes Obes Metab 15 Suppl 3: 51-60 [CrossRef] [Google Scholar] [PubMed]
  42. Gorgens SW, Eckardt K, Jensen J, Drevon CA, Eckel J (2015) Exercise and Regulation of Adipokine and Myokine Production. Prog Mol Biol Transl Sci 135: 313-336 [CrossRef] [Google Scholar] [PubMed]
  43. Astrom H, Jonsson B (1976) Design of exercise test, with special reference to heart patients. Br Heart J 38: 289-296 [CrossRef] [Google Scholar] [PubMed]
  44. Borg GA (1982) Psychophysical bases of perceived exertion. Med Sci Sports Exerc 14: 377-381 [Google Scholar] [PubMed]
  45. R&D. Elisa Kit https://www.rndsystems.com/products/elisas https://www.rndsystems.com/products/human-il-6-quantikine-hs-elisa-kit_ hs600b https://www.rndsystems.com/products/human-il-8-cxcl8-quantikine-hselisa- kit_hs800 https://www.rndsystems.com/products/human-il-1-beta-il-1f2-quantikinehs- elisa-kit_hslb00d https://www.rndsystems.com/products/human-tnf-alpha-quantikine-hselisa_ hsta00d
  46. Analysportalen http://analysportalen-labmedicin.skane.se http://www.analysportalen-labmedicin.skane.se/pics/Labmedicin/ Analysportalen/KIT/IL-6.pdf http://www.analysportalen-labmedicin.skane.se/pics/Labmedicin/ Analysportalen/KIT/IL-8.pdf http://www.analysportalen-labmedicin.skane.se/pics/Labmedicin/ Analysportalen/KIT/TNF.pdf http://www.analysportalen-labmedicin.skane.se/pics/Labmedicin/ Analysportalen/KIT/IL.pdf Laboratory Medicine, Skåne University Hospital, 2017
  47. Norton K, Norton L, Sadgrove D (2010) Position statement on physical activity and exercise intensity terminology. J Sci Med Sport 13: 496-502 [CrossRef] [Google Scholar] [PubMed]
  48. WHO. Body mass index - BMI
  49. Saleem M, Herrmann N, Swardfager W, Eisen R, Lanctot KL (2015) Inflammatory Markers in Mild Cognitive Impairment: A Meta-Analysis. J Alzheimers Dis 47: 669-679 [CrossRef] [Google Scholar] [PubMed]
  50. Hallberg L, Janelidze S, Engstrom G, Wisen AG, Westrin A, et al. (2010) Exercise-induced release of cytokines in patients with major depressive disorder. J Affect Disord 126: 262-267 [CrossRef] [Google Scholar] [PubMed]
  51. Gmiat A, Micielska K, Kozlowska M, Flis DJ, Smaruj M, et al. (2017) The impact of a single bout of high intensity circuit training on myokines' concentrations and cognitive functions in women of different age. Physiol Behav 179: 290-297 [CrossRef] [Google Scholar] [PubMed]
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