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International Journal of Physical Therapy & Rehabilitation Volume 3 (2017), Article ID 3:IJPTR-138, 9 pages
https://doi.org/10.15344/2455-7498/2017/138
Research Article
Special Issue: Various Approaches for Rehabilitation Science
Exercise-induced Release of Cytokines/Myokines in a Single Exercise Test before and after a Training Intervention in Patients with Mild Cognitive Impairment

Marie E. Bengtsson-Lindberg1, Lotta Wilke2, Susanna Vestberg3, Helene Jacobsson4 and Anita Wisén5*

1Clinical Memory Researh Unit, Dept. of Clinical Sciences, Malmö, Lund University, Sweden
2Biomedical analyst,Laboratory Medicine, Skåne University Hospital, Clinical Immunology and Transfusion Medicine, Division of immunology, Lund, Sweden
3Department of Psychology, Lund University, Sweden
4Unit for Medical Statistics and Epidemiology, Clinical Studies Sweden – Forum South, Skåne University Hospital, Lund, Sweden
5Physiotherapy research group, Department of Health Sciences, Lund University, Sweden
Dr. Anita Wisén, Physiotherapy research group, Department of Health Sciences, Lund University, Sweden, Tel: +46 76 580 15 14; E-mail: anita.wisen@med.lu.se
22 August 2017; 02 October 2017; 04 October 2017
Bengtsson-Lindberg ME, Wilke L, Vestberg S, Jacobsson H, Wisén A (2017) Exercise-induced Release of Cytokines/Myokines in a Single Exercise Test before and after a Training Intervention in Patients with Mild Cognitive Impairment. Int J Phys Ther Rehab 3: 138. doi: https://doi.org/10.15344/2455-7498/2017/138
This study was supported by Ribbingska memory-foundation,Greta and Johan Kocks foundations, Region Skåne and the Memory Clinic at Skåne University Hospital, Lund, Sweden.

Abstract

Background: Inflammation may play an important role in development of mild cognitive impairment and also predict progression of cognitive diseases. Studies have shown that aerobic and strength training increases the ability to generate and secrete cytokines from the skeletal muscles (then named myokines) that might be protective.
Objectives: This pilot study was intended to explore if it is possible to detect changes in cytokine/myokine levels in response to a single exercise test in patients with mild cognitive impairment before and after a training intervention.
Participants and Methods: Participants with mild cognitive impairment (N=33) performed12 weeks aerobic and strength endurance training at moderate (n=13), at high intensity (n=12) or served as control group with no training (n=8). At baseline and after 12 weeks a single maximal exercise test was performed where 2 venous blood samples were collected respectively, one at rest and one at maximal workload. TNF-α, IL-6, IL-1β, and IL -8 were assayed using commercial ELISA kits.
Results: Resting values of TNF-α, IL-6, IL-1β, or IL -8 at base line and post training were normal compared to reference values for all patients.
At baseline, a single exercise test elevated levels of the myokines, IL-6 (p= 0.002), TNF-α (p<0.001) and IL-8 (p=0.020) in the total group of participants.
After a training period of 12 weeks, a single exercise test elevated levels of the myokines IL-6 and IL-1β in the moderate intensity group(p= 0.002 and p=0.011 respectively) and in the high intensity group (p=0.003 and p=0.037 respectively). A reduction of the cytokine IL-6 (p=0.05) at rest was seen in high intensity group.
Conclusion: Our results indicate that the method to explore cytokines/myokines using a single exercise test could be a useful complement to simply analysing resting values of cytokines, and that positive protective effect of training thus might be detectable.