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International Journal of Clinical Research & Trials Volume 5 (2020), Article ID 5:IJCRT-146, 5 pages
https://doi.org/10.15344/2456-8007/2020/146
Review Article
Hypothyroidism and Heart Failure: Epidemiology, Pathogenetic Mechanisms & Therapeutic Rationale

Jonathan Francois, Mohammed Al-Sadawi, Joseph Casillas, Evan Botti, Lina Soni, Debora Ponse, Scarlett Maria Decamps, and Samy I. McFarlane*

Department of Medicine, SUNY-Downstate Health Science University, Brooklyn, New York, USA
Prof. Samy I. McFarlane, College of Medicine, Department of Medicine, Division of Endocrinology, Internal Medicine Residency Program Director, State University of New York, Downstate Medical Center, 450 Clarkson Ave, Box 50, Brooklyn, New York, USA, Tel 718-270-6707, Fax 718-270- 4488; E-mail: smcfarlane@downstate.edu
25 March 2020; 30 May 2020; 01 June 2020
Francois J, Al-Sadawi M, Casillas J, Botti E, Soni L, et al. (2020) Hypothyroidism and Heart Failure: Epidemiology, Pathogenetic Mechanisms & Therapeutic Rationale Int J Clin Res Trials 5: 146. doi: https://doi.org/10.15344/2456-8007/2020/146

Abstract

Heart Failure (HF) is a major public health problem and a major cause of morbidity and mortality worldwide. Thyroid hormones (TH) have multiple effects on the heart and cardiovascular system. In recent years, studies have shown that hypothyroidism, including subclinical hypothyroidism, is associated with an increased risk for developing and worsening of HF. This review addresses the relationship between HF and hypothyroidism by highlighting the epidemiology, pathophysiology and management.