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International Journal of Clinical Research & Trials Volume 3 (2018), Article ID 3:IJCRT, 07 pages
https://doi.org/10.15344/2456-8007/2018/124
Research Article
Current Efficacy of the First Line Uncomplicated Malaria Treatment in Two Sentinels Sites of Côte d’Ivoire

Offianan Andre Toure*1, N’Guessan Tiacoh Landry1, Ira Bonouman Ama Valerie1, Assi Serge Brice2, Kouame Emmanuel1, Kokora Adonis1, Yao Serge Stephane1, Amata Eric3, Kinifo-Lawson Viviane4, Adji Eric Gbessi1, Beourou Sylvain1, Tuo Karil1, Ako Ako Aristide Berenger1, Gnondjui Albert1, Djaman Joseph5,6 and Jambou Ronan1,7

1Unité de Paludologie, Institut Pasteur Côte d’Ivoire, Côte d’Ivoire
2Institut Pierre Richet Bouake/Programme National de Lutte contre le Paludisme, Abidjan Côte d’Ivoire, Côte d’Ivoire
3Formation Sanitaire Urbaine à Base Communautaire d’Anonkoua-Kouté Abidjan, Côte d’Ivoire
4Centre de Santé Urbain de Libreville, Man, Côte d’Ivoire
5Département de Biochimie Clinique et Fondamentale, Institut Pasteur Côte d’Ivoire
6Laboratoire de Pharmacodynamie-Biochimique UFR Biosciences, Université Félix Houphouët-Boigny Abidjan, Côte d’Ivoire
7Département de Parasitologie et Insectes vecteurs, Institut Pasteur Paris France, France
Dr. Offianan Andre Toure, Unité de Paludologie, Institut Pasteur Côte d’Ivoire, Côte d’Ivoire; E-mail: andre_offianan@yahoo.fr
19 October 2017; 01 March 2018; 03 March 2018
Toure OA, Landry NT, Valerie IBA, Brice AS, Emmanuel K, et al. (2018) Current Efficacy of the First Line Uncomplicated Malaria Treatment in Two Sentinels Sites of Côte d’Ivoire. Int J Clin Res Trials 3: 124. doi: https://doi.org/10.15344/2456-8007/2018/124
The National Malaria Control Program of Côte d’Ivoire and WHO Global Fund sponsored this trial.

References

  1. World Health Organization (2016) World malaria report [View]
  2. World Health Organization (2015) Guidelines for the treatment of malaria. 3nd edition. Geneva: WHO Press [Google Scholar]
  3. Dondorp AM, Yeung S, White L, Nguon C, Day NP, et al. (2010) Artemisinin resistance: current status and scenarios for containment. Nat Rev Microbiol: 8: 272-280 [CrossRef] [Google Scholar] [PubMed]
  4. Phyo AP, Nkhoma S, Stepniewska K, Ashley EA, Nair S, et al. (2012) Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study. Lancet 379: 1960-1966 [CrossRef] [Google Scholar] [PubMed]
  5. World Health Organization (2009) Methods for surveillance of antimalarial drug efficacy. Geneva: World Health Organization [Google Scholar]
  6. Ariey F, Witkowsky B, Amaratunga C, Beghain J, Langlois AC, et al. (2014) A molecular marker of artemisinin resistant Plasmodium falciparum. Nature 505: 50-55 [CrossRef] [Google Scholar] [PubMed]
  7. Offianan AT, Assi SB, Tiacoh LN, Gbessi EA, Ako AB, et al. (2014) Open label, randomized, non-inferiority clinical trial of artesunate-amodiaquine versus artemether-lumefantrine fixed-dose combinations in children and adults with uncomplicated falciparum malaria in Cote d'Ivoire. Malar J 13: 439 [CrossRef] [Google Scholar] [PubMed]
  8. WHO (2000) Severe falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene [Google Scholar]
  9. WHO (2006b) WHO child growth standards: length/height-for-age, weightfor- age, weight-for-length, weight-for-height and body mass index-forage: methods and development. Geneva: World Health Organization, Multicentre Growth Reference Study Group [Google Scholar]
  10. MMV/WHO (2007) Methods and techniques for clinical trials on antimalarial drug efficacy: genotyping to identify parasite populations. Amsterdam, The Netherlands: WHO
  11. Noedl H, Socheat D, Satimai W (2009) Artemisinin-resistant malaria in Asia. N Engl J Med 361: 540-541 [CrossRef] [Google Scholar] [PubMed]
  12. Dondorp AM, Nosten F, Yi P, Das D, Phyo AP, et al. (2009) Artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med 361: 455-467 [Google Scholar]
  13. Nyunt MH, Soe MT, Myint HW, Oo HW, Aye MM, et al. (2017) Clinical and molecular surveillance of artemisinin resistant falciparum malaria in Myanmar (2009-2013). Malar J 16: 333 [CrossRef] [Google Scholar] [PubMed]
  14. Ashley EA, Stepniewska K, Lindegårdh N, McGready R, Annerberg A, et al (2007) Pharmacokinetic study of artemether-lumefantrine given once daily for the treatment of uncomplicated multidrug-resistant falciparum malaria. Trop Med Int Health 12: 201-208 [CrossRef] [Google Scholar] [PubMed]
  15. World Wide Antimalarial Resistance Network (WWARN) Lumefantrine PK/PD Study Group (2015) Artemether-lumefantrine treatment of uncomplicated Plasmodium falciparum malaria: a systematic review and meta-analysis of day 7 lumefantrine concentrations and therapeutic response using individual patient data. BMC Med 13: 227 [CrossRef] [Google Scholar] [PubMed]
  16. Ayogu EE, Ukwe CV, Nna EO (2015) Therapeutic Efficacy of Artemether- Lumefantrine for Treatment of Uncomplicated Plasmodium falciparum Malaria in Enugu, Nigeria. Tropical Journal of Pharmaceutical Research; 14: 1487-1493 [CrossRef] [Google Scholar]
  17. Menan H, Faye O, Same-Ekobo A, Oga ASS, Faye B, et al. (2011) Comparative study of the efficacy and tolerability of dihydroartemisininpiperaquine- trimethoprim versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroon, Ivory Coast and Senegal. Malar J 10: 185 [CrossRef] [Google Scholar] [PubMed]
  18. Offianan AT, Menan GK, Yapi JD, Ako AAB, Khali D, et al. (2011) Artesunate/mefloquine paediatric formulation vs. artemether/lumefantrine for the treatment of uncomplicated Plasmodium falciparum in Anonkoua koute, Côte d’Ivoire. Trop Med Int Health, 16: 290-297 [CrossRef] [Google Scholar]
  19. Toure Offianan A, Assi SB, Aristide MA C, N’guessan LT, Ako AA, et al. (2011) Assessment of the efficacy of first-line antimalarial drugs after 5 years of deployment by the National Malaria Control Programme in Côte d’Ivoire. Open Access Journal of Clinical Trials, 3: 67-76 [CrossRef] [Google Scholar]
  20. Faye B, Kuété T, Kiki-Barro CP, Tine RC, Nkoa T, et al. (2012) Multicentre study evaluating the non-inferiority ofthe new paediatric formulation of artesunate/amodiaquine versus artemether/lumefantrine for the management of uncomplicated Plasmodium falciparum malaria in children in Cameroon, Ivory Coast and Senegal. Malar J 11: 433 [Google Scholar]
  21. Toure OA, Valecha N, Tshefu AK, Thompson R, Krudsood S, et al. (2016) A Phase 3, Double-Blind, Randomized Study of Arterolane Maleate- Piperaquine Phosphate vs Artemether-Lumefantrine for Falciparum Malaria in Adolescent and Adult Patients in Asia and Africa. Clinical Infectious Diseases 62: 964-971 [CrossRef] [Google Scholar] [PubMed]
  22. Yavo W, Konaté A, Kassi FK, Djohan V, Angora KE, et al. (2015) Efficacy and Safety of Artesunate-Amodiaquine versus Artemether Lumefantrine in the Treatment of Uncomplicated Plasmodium falciparum Malaria in Sentinel Sites across Côte d’Ivoire. Malar Res Treat 2015: 878132 [CrossRef] [Google Scholar] [PubMed]
  23. Dorkenoo AM, Yehadji D, Agbo YM, Layibo Y, gbeko F, et al. (2016) Therapeutic efficacy trial of artemisinin-based combination therapy for the treatment of uncomplicated malaria and investigation of mutations in K13 propeller domain in Togo, 2012-2013. Malar J 15: 331 [CrossRef] [Google Scholar] [PubMed]
  24. Ogouyèmi-Hounto A, Azandossessi C, Lawani S, Damien G, SissintoSavi de Tove Y, et al. (2016) Therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in northwest Benin. Malar J 15: 37 [CrossRef] [Google Scholar] [PubMed]
  25. Plucinski MM, Dimbu PR, Macaia AP, Ferreira CM, Samutondo C, et al. (2017) Efficacy of artemether-lumefantrine, artesunate-amodiaquine, and dihydroartemisinin-piperaquine for treatment of uncomplicated Plasmodium falciparum malaria in Angola, 2015. Malar J 16: 62 [CrossRef] [Google Scholar] [PubMed]
  26. Salvador C, Rafael B, Matsinhe F, Candrinho B, Muthemba R, et al. (2017) Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria at sentinel sites in Mozambique, 2015. Acta Trop 171: 146-150 [CrossRef] [Google Scholar] [PubMed]
  27. Tinto H, Diallo S, Zongo I, Guiraud I, Valea I, et al. (2014) Effectiveness of artesunate-amodiaquine vs. artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in Nanoro, Burkina Faso a noninferiority randomised trial. Trop Med Int Health 19: 469-475 [CrossRef] [Google Scholar] [PubMed]
  28. Sondo P, Derra K, Diallo-Nakanabo S, Tarnagda Z, Zampa O, et al. (2015) Effectiveness and safety of artemether-lumefantrine versus artesunateamodiaquine for unsupervised treatment of uncomplicated falciparum malaria in patients of all age groups in Nanoro, Burkina Faso: a randomized open label trial. Malar J 14: 325 [CrossRef] [Google Scholar] [PubMed]
  29. Mutabingwa TK, Anthony D, Heller A, Hallett R, Ahmed J, et al. (2005) Amodiaquine alone, amodiaquine+sulfadoxine-pyrimethamine, amodiaquine+artesunate, and artemether-lumefantrine for outpatient treatment of malaria in Tanzanian children: a four-arm randomised effectiveness trial. Lancet 365: 1474-1480 [CrossRef] [Google Scholar] [PubMed]
  30. Piola P, Fogg C, Bajunirwe F, Biraro S, Grandesso F, et al. (2005) Supervised versus unsupervised intake of six-dose artemether-lumefantrine for treatment of acute, uncomplicated Plasmodium falciparummalaria in Mbarara, Uganda: a randomised trial. Lancet 365: 1467-1473 [CrossRef] [Google Scholar] [PubMed]
  31. Checchi F, Piola P, Fogg C, Bajunirwe F, Biraro S, et al. (2006) Supervised versus unsupervised antimalarial treatment with six-dose artemetherlumefantrine: pharmacokinetic and dosage-related findings from aclinical trial in Uganda. Malaria Journal 5: 59 [CrossRef] [Google Scholar] [PubMed]
  32. Ngasala BE, Malmberg M, Carlsson AM, Ferreira PE, Petzold MG, et al. (2011) Effectiveness of artemether-lumefantrine provided by community health workers in under-five children with uncomplicated malaria in rural Tanzania: an open label prospective study. Malaria Journal 10: 64 [CrossRef] [Google Scholar] [PubMed]