Profile
International Journal of Surgery & Surgical Procedures Volume 2 (2017), Article ID 2:IJSSP-117, 3 pages
https://doi.org/10.15344/2456-4443/2017/117
Mini Review
The Significance of a Nuclear Protein as a Moonlight Protein: Diagnostic and Therapeutic Potentials in Liver Transplantation

Shigeru Goto1,2*, Toshiaki Nakano1*, Li-Wen Hsu1, Kuei-Chen Chiang2, Yayoi Shimada2, Takeshi Goto2, Naoya Ohmori2, Shuji Sato2, Yuki Takaoaka5,4, Yasuo Magari5,4, Seiji Kawamoto6 and Chao-Long Chen1*

1Liver Transplantaion Center, Kohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
2Basic Medical Science of Nursing, Faculty of Nursing, Department of Nursing, Josai International University, Chiba, Japan
3Fukuoka Institute of Occupational Health, Fukuoka, Japan
4Clinical Medical Sciences, Chang Gung University College of Medicine, Kohsiung, Taiwan
5Q-may Laboratory Corporation, Oita, Japan
6Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, HigashiHiroshima, Japan
Dr. Shigeru Goto, Liver Transplantation Center, Kaohsiung Chang Gung Memorial Hospital, 123 Ta-Pei Rd., Niao-Sung, Kaohsiung 833, Taiwan; E-mail: s-goto@athena.ocn.ne.jp
Dr. Toshiaki Nakano, Liver Transplantation Center, Kaohsiung Chang Gung Memorial Hospital, 123 Ta-Pei Rd., Niao-Sung, Kaohsiung 833, Taiwan; E-mail: toshi.nakano@msa.hinet.net
Dr. Chao-Long Chen, Liver Transplantation Center, Kaohsiung Chang Gung Memorial Hospital, 123 Ta-Pei Rd., Niao-Sung, Kaohsiung 833, Taiwan; E-mail: clchen@cgmh.org.tw
31 January 2017; 20 April 2017; 22 April 2017
Goto S, Nakano T, Hsu LW, Chiang KC, Shimada Y, et al. (2017) The Significance of a Nuclear Protein as a Moonlight Protein: Diagnostic and Therapeutic Potentials in Liver Transplantation. Int J Surg Surgical Proced 2: 117. doi: https://doi.org/10.15344/2456-4443/2017/117
This work was supported in part by Grants from the National Science Council (NSC98-2320-B-182-029-MY3; NSC98-2314-B-182A-050- MY2; NSC98-2314-B-182A-058-MY3) and the Chang Gung Memorial Hospital (CMRPD880011/2; CMRPD891671; CMRPG881081/2; CMRPG870901/2; CMRPG870051; CMRPG890721) of Taiwan. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

References

  1. Nakano T, Kawamoto S, Lai CY, Sasaki T, Aki T, et al. (2004) Liver transplantation-induced antihistone H1 autoantibodies suppress mixed lymphocyte reaction. Transplantation 77: 1595-1603. View
  2. Hsu LW, Goto S, Nakano T, Lai CY, Kao YH, et al. (2005) The effects of anti-histone H1 antibody on immune cells responsible for rejection reaction. Molecular Immunology 42: 1155-1164. View
  3. Nakano T, Goto S, Lai CY, Hsu LW, Kao YH, et al. (2007) Experimental and clinical significance of anti-nuclear antibodies in liver transplantation. Transplantation 83: 1122-1125. View
  4. Shimada Y, Goto T, Kawamoto S, Kiso T, Katayama A, et al. (2008) Development of a two-step chromatography procedure that allows the purification of a high-purity anti-histone H1 monoclonal immunoglobulin M antibody with immunosuppressant activity. Biomed Chromatogr 22: 13-19. View
  5. Katayama A, Kawamoto S, Yamanaka Y, Kiso T, Aki T, et al. (2008) Antihistone H1 autoantibody: An inducible immunosuppressive factor in liver transplantation. Animal Cell Technology: Basic & Applied Aspects 15: 137-143. View
  6. Yamanaka Y, Kawamoto S, Katayama A, Kiso T, Aki T, et al. (2008) Anti-histone H1 autoantibody directly acts on T cells to exert its immunosuppressive activity. Animal Cell Technology: Basic & Applied Aspects 15: 153-158. View
  7. Nakano T, Chen CL, Goto S (2013) Nuclear antigens and auto/ alloantibody responses: Friend or foe in transplant immunology. Clinical & Developmental Immunology 2013: 267156. View
  8. Jeffery CJ (2003) Moonlighting proteins: old proteins learning new tricks. Trends Genet 19: 415-417. View
  9. Pereira SL, Reeve JN (1998) Histones and nucleosomes in Archaea and Eukarya: a comparative analysis. Extremophiles 2: 141-148. View
  10. Konishi A, Shimizu S, Hirota J, Takao T, Fan Y, et al. (2003) Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks. Cell 114: 673-688. View
  11. Jonathan D Gilthorpe, Fazal Oozeer1, Julia Nash, Margarita Calvo, David LH Benn tt, Andrew Lumsden. (1998) Extracellular histone H1 is neurotoxic and drives a pro-inflammatory response in microglia. J Clin Invest 102: 283-293. View
  12. Hsu LW, Chen CL, Nakano T, Lai CY, Chiang KC, et al. (2008) The role of a nuclear protein, histone H1 on signaling pathways for the maturation of dendritic cells. Clin Exp Immunol 152: 576-584. View
  13. Dumitriu IE, Baruah P, Bianchi ME, Manfredi AA, Rovere-Querini P, et al. (2005) Requirement of HMGB1 and RAGE for the maturation of human plasmacytoid dendritic cells. Eur J Immunol 35: 2184-2190. View
  14. Nakano T, Goto S, Lai CY, Hsu LW, Wong JL, et al. (2008) Involvement of autoimmunity against nuclear histone H1 in liver transplantation tolerance. Transplant Immunology 19: 87-92. View
  15. Kao YH, Jawan B, Goto S, Hung CT, Lin YC, et al. (2008) High-Mobility Group Box 1 Protein Activates Hepatic Stellate Cells In Vitro. Transplant Proc 40: 2704-2705. View
  16. Nakano T, Goto S, Lai CY, Hsu LW, Takaoka Y, et al. (2010) Immunological aspects and therapeutic significance of an auto-Ab against histone H1 in a rat model of Con A-induced hepatitis. Immunology 129: 547-555. View
  17. Goto S, Nakano T, Hsu LW, Chiang KC, Lai CY, et al. (2011) Autoimmunity and liver transplantation immunology. Current Trends in Immunology 12: 1-11.
  18. Hsu LW, Goto S, Nakano T, Chen KD, Wang CC, et al. (2012) The effect of exogenous histone H1 on rat adipose-derived stem cell proliferation, migration, and osteogenic differentiation in vitro. J Cell Physiol 227: 3417-3425. View
  19. Palumbo R, Bianchi ME (2004) High mobility group box 1 protein, a cue for stem cell recruitment. Biochem Pharmacol 68: 1165-1170. View
  20. Takaoka Y, Kawamoto S, Katayama A, Nakano T, Yamanaka Y, et al. (2013) Unexpected T cell regulatory activity of anti-histone H1 autoantibody: Its mode of action in regulatory T cell-dependent and – independent manners. Biochem Biophys Res Commun 431: 246-252. View
  21. Nakano T, Goto S, Lai CY, Hsu LW, Tseng HP, et al. (2013) Induction of antinuclear antibodies by de novo autoimmune hepatitis regulates alloimmune responses in rat liver transplantation. Clinical & Developmental Immunology 2013: 413928. View
  22. Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, et al. (1999) HMG-1 as a late mediator of endotoxin lethality in mice. Science 285: 248- 251. View
  23. Scaffidi P, Misteli T, Bianchi ME (2002) Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418: 191-195. View
  24. Harris HE, Raucci A (2006) Alarmin(g) news about danger: workshop on innate danger signals and HMGB1. EMBO Rep 7: 774-778. View
  25. Chavakis E, Hain A, Vinci M, Carmona G, Bianchi ME, et al. High-mobility group box 1 activates integrin-dependent homing of endothelial progenitor cells. Circ Res 100: 204-212. View
  26. Palumbo R, Sampaolesi M, De Marchis F, Tonlorenzi R, Colombetti S, et al. (2004) Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation. J Cell Biol 164: 441-449. View
  27. Sadamura-Takenaka Y, Ito T, Noma S, Oyama Y, Yamada S, et al. (2014) HMGB1 Promotes the Development of Pulmonary Arterial Hypertension in Rats. PLoS ONE 9: e102482. View
  28. Nakahara M1, Ito T, Kawahara K, Yamamoto M, Nagasato T, et al. (2013) Recombinant Thrombomodulin Protects Mice against Histone- InducedLethal Thromboembolism. PLoS ONE 8: e75961. View
  29. Barnay-Verdier S, Fattoum L, Borde C, Kaveri S, Gibot S, et al. (2011) Emergence of autoantibodies to HMGB1 is associated with survival in patients with septic shock. Intensive Care Med 37: 957-962. View
  30. Hatada T, Wada H, Nobori T, Okabayashi K, Maruyama K, et al. (2005) Plasma concentrations and importance of High Mobility Group Box protein in the prognosis of organ failure in patients with disseminated intravascular coagulation. Thromb Haemost 94: 975-979. View
  31. Ito T, Kawahara K, Nakamura T, Yamada S, Nakamura T, et al. (2007) High-mobility group box 1 protein promotes development of microvascular thrombosis in rats. J Thromb Haemost 5: 109-116. View
  32. Kusano T, Chiang KC, Inomata M, Shimada Y, Ohmori N, et al. (2015) A novel anti-histone H1 monoclonal antibody, SSV monoclonal antibody, improves lung injury and survival in a mouse model of lipopolysaccharideinduced sepsis like syndrome. BioMed Research International 2015: 491649. View
  33. Nakano T, Kamei R, Fujimura T, Takaoka Y, Hori A, et al. (2016) Impact of Histone H1 on the Progression of Allergic Rhinitis and Its Suppression by Neutralizing Antibody in Mice. PLoS One 11: e0153630. View
  34. Chiang KC, Shimada Y, Nakano T, Lai CY, Hsu LW, et al. (2009) A Novel Peptide Mimotope Identified as a Potential Immunosuppressive Vaccine for Organ Transplantation. Journal of Immunology 182: 4282-4288. View