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International Journal of Gastroenterology Disorders & Therapy Volume 4 (2017), Article ID 4:IJGDT-132, 5 pages
https://doi.org/10.15344/2393-8498/2017/132
Original Article
Association Between Mannose Binding Lectin Level and Progression of Chronic Hepatitis B

Elife Erarslan1*, Barış Yılmaz1, Yusuf Coşkun1, Aydın Çifçi2, Fuat Ekiz1, Zeynep Giniş3, Şahin Çoban1 and İlhami Yüksel1

1DışkapıYıldırımBeyazıt Training and Research Hospital, Department of Gastroenterology, Ankara, Turkey
2Kırıkkale University Medical School, Department of Internal Medicine, Kırıkkale, Turkey
3DışkapıYıldırımBeyazıt Training and Research Hospital, Department of Biochemistry, Ankara, Turkey
Dr. Elife Erarslan, DışkapıYıldırımBeyazıt Training and Research Hospital, Department of Gastroenterology, İrfan BaştuğCaddesi, ZIP code: 06110, Dışkapı/Ankara, Turkey; E-mail: elifeerarslan@gmail.com
16 October 2017; 06 December 2017; 08 December 2017
Erarslan E, Yılmaz B, Coşkun Y, Çifçi A, Ekiz F, et al. (2017) Association Between Mannose Binding Lectin Level and Progression of Chronic Hepatitis B. Int J Gastroenterol Disord Ther 4: 132. doi: http://dx.doi.org/10.15344/2393-8498/2017/132

Abstract

Background: Mannose binding lectin (MBL) is believed to be an important component of the innate immune response. MBL may be an important non-invasive predictor for progression of hepatitis B virus infection. In this study, we examined whether there is a relationship between MBL levels and progression of hepatitis B virus infection.
Methods: In this cross-sectional study, fifty patients with chronic hepatitis B and 21healthy control subjects were included. They were classified into three groups: Active hepatitis B, inactive hepatitis B and healthy control groups. The association between MBL level with the stage of fibrosis and histological activity index (HAI) was found in patients with active chronic hepatitis B.
Results: The mean ± SD of MBL level was as 2875.3 ± 2040.03 ng/ml in active HBV patients, 2463.9 ± 1915.4 ng / ml in inactive HBV patients, and 1865.04 ± 265.6 ng/ml in healthy controls (P: 0.344). MBL was not significantly correlated with HAI and the stage of fibrosis (r: -0.30, P: 0.876 and r: 0.077, P: 0.687, respectively).
Conclusion: In our study, we could not find any significant association between MBL levels and progression of HBV infection; which is not in line with the hypothesis that MBL may be beneficial as a non-invasive predictor of the survival of patients with hepatitis B virus infection.