Impact of Acotiamide Affects Meal-related Symptoms and Lower Abdominal Symptoms in Functional Dyspepsia in Japan

doi:10.15344/2393-8498/2014/109

Graphy

Profile

New User

New to Graphy Publications? Create an account to get started today.

Create Account For:

Registered Users

Have an account? Sign in now.

Article Menu

Journal Menu

How to Cite | Author Information | Publication History

International Journal of Gastroenterology Disorders & Therapy Volume 1 (2014), Article ID 1:IJGDT-109, 4 pages
http://dx.doi.org/10.15344/2393-8498/2014/109

Research Article

Impact of Acotiamide Affects Meal-related Symptoms and Lower Abdominal Symptoms in Functional Dyspepsia in Japan

Hiroshi Yamawaki , Seiji Futagami^*, Mayumi Shimpuku, Hitomi Sato, Tetsuro Kawagoe, Tomotaka Shindo, Hiroyuki Nagoya, Yasuhiro Kodaka, Choitsu Sakamoto

Department of Gastroenterology, Nippon Medical School, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan

Corresponding Author Details: Dr. Seiji Futagami, MD, PhD, Department of Gastroenterology, Nippon Medical School, Graduate School of Medicine, 1-1- 5 Sendagi, Bunkyo-ku, Japan, Tel: +81-3-3822-2131; Fax: +81-3-5685-1793; E-mail: seiji.futagami@gmail.com

Received: 18 October 2014; Accepted: 18 November 2014; Published: 20 November 2014

Citation: Yamawaki H, Futagami S, Shimpuku M, Sato H, Kawagoe T, et al. (2014) Impact of Acotiamide Affects Meal-related Symptoms and Lower Abdominal Symptoms in Functional Dyspepsia in Japan. Int J Gastroenterol Disord Ther 1: 109. doi: http://dx.doi.org/10.15344/2393-8498/2014/109

Copyright: © 2014 Yamawaki et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: To clarify whether acotiamide improve postprandial distress symptoms and lower abdominal symptoms through affecting hypothalamic-pituitary-adrenal (HPA) axis in FD patients.

Methods: We used Rome III criteria to evaluate upper and lower abdominal symptoms. Twenty-five functional dyspepsia (FD) patients were treated with acotiamide (300mg/day) for 4 weeks. Anxiety was evaluated using STAI-state/-trait. We measured ACTH and cortisol levels in FD patients.

Results: Acotiamide treatment significantly (p=0.007, p=0.003) improved postprandial fullness and early satiety in 4 weeks treatment in FD patients compared to those in pretreatment. In contrast, acotiamide treatment improved lower abdominal symptoms, while insignificantly. Acotiamide did not also affect anxiety using STAI-state/-trait. Acotiamide treatment for 4 weeks did not affect ACTH and cortisol levels in FD patients.

Conclusion: Further studies will be needed to clarify how acotiamide improve clinical symptoms in FD patients.

Best viewed in Mozilla Firefox, Google Chrome, Safari, Above IE 9.0 version