Distinct Associations Between Depression Status and Initial Phase of Gastric Emptying in Functional Dyspepsia and Healthy Volunteers

doi:10.15344/2393-8498/2014/106

Graphy

Profile

New User

New to Graphy Publications? Create an account to get started today.

Create Account For:

Registered Users

Have an account? Sign in now.

Article Menu

Journal Menu

How to Cite | Author Information | Publication History | Funding Information

International Journal of Gastroenterology Disorders & Therapy Volume 1 (2014), Article ID 1:IJGDT-106, 6 pages
http://dx.doi.org/10.15344/2393-8498/2014/106

Research Article

Distinct Associations Between Depression Status and Initial Phase of Gastric Emptying in Functional Dyspepsia and Healthy Volunteers

Mayumi Shimpuku¹, Seiji Futagami^1*, Masahiko Inamori², Hiroshi Yamawaki¹, Hitomi Sato¹, Yasuhiro Kodaka¹, Hiroyuki Nagoya¹, Katya Gudis¹, Tetsuro Kawagoe¹, Fumihito Saitow³, Hidenori Suzuki³ and Choitsu Sakamoto¹

¹Department of Gastroenterology, Nippon Medical School, Graduate School of Medicine, 1-1-5 Sendagi, Bunkyo-ku, Japan
²Gastroenterology Division, Yokohama City University Hospital, Yokohama, 236-0004, Japan
³Department of Pharmacology, Nippon Medical School, Graduate School of Medicine, 1-1-5 Sendagi, Bunkyo-ku, Japan

Corresponding Author Details: Dr. Seiji Futagami, MD, PhD, Department of Gastroenterology, Nippon Medical School, Graduate School of Medicine, 1-1-5 Sendagi, Bunkyo-ku, Japan,; E-mail: seiji.futagami@gmail.com

Received: 04 July 2014; Accepted: 24 September 2014; Published: 26 September 2014

Citation: Shimpuku M, Futagami S, Inamori M, Yamawaki H, Sato H, et al. (2014) Distinct Associations Between Depression Status and Initial Phase of Gastric Emptying in Functional Dyspepsia and Healthy Volunteers. Int J Gastroenterol Disord Ther 1: 106. doi: http://dx.doi.org/10.15344/2393-8498/2014/106

Funding: This work was supported in part by grants from the Ministry of Education, Culture, and Science and from the Ministry of Health, Japan.

Copyright: © 2014 Shimpuku et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background/Aims: The association between initial phase of gastric emptying and clinical symptoms and depression status in functional dyspepsia has not been studied in detail. Methods: The subjects were 20 patients with Rome III-based functional dyspepsia and healthy volunteers. We evaluated upper abdominal symptoms using GDSS score and used Self-Rating Questionnaire for Depression (SRQ-D) scores to determine depression status. Gastric motility was evaluated with the ¹³C-acetate breath test.

Results: AUC₁₅ value as initial gastric emptying within 15 mins in FD patients was significantly higher compared to that in healthy volunteers. T_max value as a marker of delayed gastric emptying in FD patients was also significantly higher compared to that in healthy volunteers. There were not significant relationships between clinical symptoms and AUC₅ and AUC₁₅ values in FD patients and healthy volunteers. In contrast, there were significant correlations (p=0.047, p=0.049) between SRQ-D score and AUC₅ and AUC₁₅ values in healthy volunteers, albeit there were not significant correlations in FD patients.

Conclusion: Impairment of AUC₁₅ or AUC₁₅/AUC_inf as well as delayed gastric emptying would play important roles in functional dyspepsia. Further studies are necessary to clarify whether various clinical symptoms and depression status are related to initial gastric emptying at postprandial 15 mins phase.

Best viewed in Mozilla Firefox, Google Chrome, Safari, Above IE 9.0 version