The Accuracy of Liver Biopsy to Diagnose Biliary Atresia: A Meta-Analysis

doi:10.15344/2456-8007/2020/144

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International Journal of Clinical Research & Trials Volume 5 (2020), Article ID 5:IJCRT-144, 10 pages
https://doi.org/10.15344/2456-8007/2020/144

Meta-analysis

The Accuracy of Liver Biopsy to Diagnose Biliary Atresia: A Meta-Analysis

Yuan Yang¹, Xin Li² and Jianghua Zhan^1,*

¹Department of Pediatric Surgery, Tianjin Children’s Hospital, Tianjin, 300074, China
²Department of General Pediatric Surgery, Urumqi First People's Hospital(Urumqi Children's Hospital), Xinjiang Uygur Autonomous Region, 830002,China

Corresponding Author Details: Dr. Jianghua Zhan, Department of Pediatric Surgery, Tianjin Children's Hospital, LongYan Road 238, Beichen District, Tianjin, 300134, China; E-mail: zhanjianghuatj@163.com

Received: 17 February 2020; Accepted: 14 March 2020; Published: 16 March 2020

Citation: Yang Y, Li X, Zhan J (2020) The Accuracy of Liver Biopsy to Diagnose Biliary Atresia: A Meta-Analysis. Int J Clin Res Trials 5: 144. doi: https://doi.org/10.15344/2456-8007/2020/144

Funding: This work was partially supported by Natural science foundation of xinjiang uygur autonomous region: The mechanism of Notch pathway in hepatic fibrosis of biliary atresia (2019D01A12). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright: © 2020 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objectives: A lot of prolonged jaundice patients may undergo many tests before confirmed diagnosis. Liver biopsy is an effective way in final stage of the course. This article aims to evaluate the accuracy of liver biopsy to diagnose biliary atresia (BA) in infants with cholestasis.
Methods: We searched Pubmed, EMBASE and the Web of Science databases for articles evacuated the accuracy of liver biopsy to diagnose BA to obtain the sensitivity, specificity, TN, FN, FP, TP. The methodological quality of liver biopsy was assessed with version 2 of the Quality Assessment of Diagnostic Accuracy Studies tool. Screening, data extraction, and quality assessment were done in duplicated.
Results: A total of 20 articles were included. The whole data results the Diagnostic Odds Ratio of liver biopsy was 170.39 (84.90 to 341.97), with a pooled sensitivity of 92% (90%-94%), pooled specificity of 95% (93%-95%).
Conclusion: Quantitative analysis demonstrated liver biopsy to be high sensitivity, high specificity, high accuracy in diagnosing BA. The data analysis provides evidence of liver biopsy is a reliable diagnosis method to confirm diagnosis.

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