Abstract

The purpose of this study is to analyze the independent clinical, laboratory, dialysis factors between a disease-specific score for cardiac risk stratification and the Quality of life (QOL) application in hemodialysis (HD) patients. A total of 43 end-stage renal disease patients (female 17 and male 26) on regular HD were included. They were clinically stable with a mean Kt/V (Daugirdas) 1.76±0.41 and mean dialysis 7.4±0.94 years. Patients answered the Kidney Disease Quality of Life questionnaire short form (KDQOL-SF) which includes the physical and mental health component (PHC, MHC). Application of a previously validated cardiac risk score (CRS) using cardiac history (A), dialysis duration (B), body mass index (C) and serum phosphate (D) multiplied by various hazards ratio (HR) was also investigated retrospectively. CRS (A+B+C+D)< 50 allocated low risk, and CRS≥50 stands for high risk of future cardiac events. The impact of various factors on CRS and KDQOL-SF was estimated by multivariate analysis using SPSS 10.0 depending on variables characteristics.

Most of the KDQOL-SF scores specific for dialysis significantly correlated with Hct, albumin, electrolytes, age, dose of HD and social support (P<0.01). CRS≥50 was found in 19 patients and 6 had cardiac events after electrocardiography and cardiac stress imaging proven in the following observed 9 months period. CRS< 50 were in the remaining 24 patients with 1 cardiac event occurred. Physical health component (PHC) and mental health component (MHC) in QOL were significant in CRS≥50 group (P<0>