Abstract

Background: Neonatal sepsis is one of the most common and serious disease that affect a large number of newborns around the world. The Cluster of Differentiation 64 (CD64) molecules can be used as a biomarker in the diagnosis of neonatal sepsis. The literatures had documented that neutrophil CD64 expression is a better diagnostic marker in sepsis than Procalcitonin (PCT), C- reactive protein (CRP) and white blood cell count (WBCs). The aim of this study was to detect relation between CD64 and neonatal sepsis, compare the differences in the CD64 index with some laboratory parameters which are WBCs, CRP, PCT, the hematological sepsis score (HSS) and the clinical indicators among the control and sepsis group.
Methods: The study was carried out in the neonatal intensive care unit and clinical pathology department at Zagazig University Hospital on 15 cases group and 15 controls group during the period from January 2019 to December 2019. Firstly, upon suspicion of neonatal sepsis, all patients were subjected to the following: history talking, clinical examination and the following investigations WBCs, CRP, PCT and blood culture were done. Then, CD64 index were measured for all cases and controls.
Results: There was significant increase in HSS, PCT, CRP, WBCs and CD64 Index among cases than control. CD64 index was positively correlated with CRP. The sensitivities of CD64, PCT, CRP, and WBCs were 96%, 80%, 93.3% and 80%respectively. However, the Specificities of The CD64, PCT, CRP and WBCs were 86%, 100%, 93.3% and 80% respectively. Blood culture is the “gold standard” for detection of infection.
Conclusion: CD64 index is a highly sensitive marker for the diagnosis of suspected neonatal sepsis. Our findings suggest that CD64 index may be incorporated as a new marker to diagnose infection especially in early diagnosis of neonatal sepsis.