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International Journal of Pediatrics & Neonatal Care Volume 5 (2019), Article ID 5:IJPNC-152, 6 pages
https://doi.org/10.15344/2455-2364/2019/152
Case Study
Assessment of Risk Factors, which Affect the Presence of Inhibitors in Children with Hemophilia A: The Albanian Case-control Study

Arlind Deveja1, Donjeta Bali2, Mirela Xhafa2, Mirzana Kapllanaj2, Etleva Refatllari3 and Anila Godo4,*

1Department of Pediatrics, University Hospital Center ‘Mother Teresa’ Tirana, Albania
2Pediatric Hematologist/Oncologist, University Hospital Center ‘Mother Teresa’ Tirana, Albania
3Laboratory of Clinical Chemistry and Hematology, University Hospital Center ‘Mother Teresa’ Tirana, Albania
4Pediatric Hematologist/Oncologist, Chief of Department of Pediatrics, University Hospital Center ‘Mother Teresa’ Tirana
Dr. Anila Godo, Pediatric Hematologist/Oncologist, Chief of Department of Pediatrics, University Hospital Center ‘Mother Teresa’ Tirana, Albania; E-mail: godoanila@gmail.com
07 February 2019; 23 April 2019; 25 April 2019
Deveja A, Bali D, Xhafa M, Kapllanaj M, Refatllari E, et al. (2019) Assessment of Risk Factors, which Affect the Presence of Inhibitors in Children with Hemophilia A: The Albanian Case-control Study. Int J Pediatr Neonat Care 5: 152. doi: https://doi.org/10.15344/2455-2364/2019/152

References

  1. Astermark J, Berntorp E, White G, Kroner B (2001) The Malmo International Brother Study (MIBS): further support for genetic predisposition to inhibitor development. Haemophilia 7: 267-272. [CrossRef] [Google Scholar] [PubMed]
  2. Franchini M, Mannucci P (2012) Past, present and future of hemophilia: a narrative review. Orphanet J Rare Dis 7: 24. [CrossRef] [Google Scholar] [PubMed]
  3. Gouw SC, van den Berg HM, Fischer K, Auerswald G, Carcao M et al. (2013) Intensity of factor VIII treatment and inhibitor development in children with severe hemophilia A: the RODIN study. Blood 121: 4046-4055. [CrossRef] [Google Scholar] [PubMed]
  4. Gouw S, Van Den Berg H, Le Cessie S, Van Der Bom J (2005) Treatment characteristics and the risk of inhibitor development: a multicenter cohort study among previously untreated patients with severe hemophilia A. J Thromb Haemost 5: 1383-1390. [CrossRef] [Google Scholar] [PubMed]
  5. Gouw S, van der Bom J, Marijke van den Berg H (2007) Treatment-related risk factors of inhibitor development in previously untreated patients with hemophilia A: the CANAL cohort study. Blood 109: 4648-4654. [CrossRef] [Google Scholar] [PubMed]
  6. Hay CR, Ollier W, Pepper L, Cumming A, Keeney S, et al. (1997) HLA Class II Profile: A Weak Determinant of Factor VIII Inhibitor Development in Severe Haemophilia A. Thromb Haemost 77: 234-237. [CrossRef] [Google Scholar] [PubMed]
  7. Kosaka N, Izumi H, Sekine K, Ochiya T (2010) microRNA as a new immuneregulatory agent in breast milk. Silence 1: 7. [CrossRef] [Google Scholar] [PubMed]
  8. Leissinger C, Cooper D, Solem C (2011) Assessing the impact of age, race, ethnicity and inhibitor status on functional limitations of patients with severe and moderately severe haemophilia A. Haemophilia 17: 884-889. [CrossRef] [Google Scholar] [PubMed]
  9. Mauser-Bunschoten E, Fischer K, van den Berg M, van der Bom J (2003) Age at first treatment and immune tolerance to factor VIII in severe hemophilia. Thromb Haemost 89: 475-479. [Google Scholar] [PubMed]
  10. Meeks S, Batsuli G (2016) Hemophilia and inhibitors: current treatment options and potential new therapeutic approaches. Hematology 2016: 657-662. [CrossRef] [Google Scholar] [PubMed]
  11. Miller C (2018) Laboratory testing for factor VIII and IX inhibitors in haemophilia: A review. Haemophilia 24: 186-197. [CrossRef] [Google Scholar] [PubMed]
  12. Schwaab R, Brackmann HH, Meyer C, Seehafer J, Kirchgesser M et al. (1995) Haemophilia A: Mutation Type Determines Risk of Inhibitor Formation. Thromb Haemost 74: 1402-1406. [Google Scholar] [PubMed]
  13. Wight J, Paisley S (2003) The epidemiology of inhibitors in haemophilia A: a systematic review. Haemophilia 9: 418-435. [CrossRef] [Google Scholar] [PubMed]
  14. Witmer C, Young G (2012) Factor VIII inhibitors in hemophilia A: rationale and latest evidence. Ther Adv Hematol 4: 59-72. [CrossRef] [Google Scholar] [PubMed]