Profile

New User

New to Graphy Publications? Create an account to get started today.

Registered Users

Have an account? Sign in now.

How to Cite | Author Information | Publication History | Funding Information
International Journal of Laboratory Medicine & Research Volume 1 (2015), Article ID 1:IJLMR-107, 3 pages
http://dx.doi.org/10.15344/2455-4006/2015/107
Commentary
Apolipoprotein E-knockout Mice as a Lifestyle-related Disease Model of Atherosclerosis and Non-alcoholic Fatty Liver Disease

Masa-Aki Shibata1*, E. Shibata2, S. Fujioka1 and M. Harada-Shiba2

1Laboratory of Anatomy & Histopathology, Graduate School of Heath Sciences, Osaka Health Science University, Japan
2Department of Molecular Innovation in Lipidology, National Cerebral & Cardiovascular Center Research Institute, Japan
Prof. Masa-Aki Shibata, Laboratory of Anatomy & Histopathology Graduate School of Heath Sciences, Osaka Health Science University, 1-9-27, Temma, Kita-ku, Osaka, 530-0043, Japan, Tel: +81-6-7506- 9046; Fax: 81-6-6352-5995; E-mail: masaaki.shibata@ohsu.ac.jp
12 October 2015; 14 October 2015; 16 October 2015
Shibata MA, Shibata E, Fujioka S, Harada-Shiba M (2015) Apolipoprotein E-knockout Mice as a Lifestyle-related Disease Model of Atherosclerosis and Non-alcoholic Fatty Liver Disease. Int J Lab Med Res 1: 107. doi: http://dx.doi.org/10.15344/2455-4006/2015/107
This work was supported by Grants-in-Aid for Scientific Research from the Japanese Ministry of Health, Labor and Welfare (H23- seisakutansaku-ippan-004. A member of this research: Dr. M.A. Shibata. The research representative: Dr. M. Harada-Shiba).
© 2015 Shibata et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

References

  1. World Health Organization. The top 10 causes of death in the world, 2000 and 2012. Fact sheet No 310; updated May 2014. View
  2. Ministry of Health, Labor and Welfare in Japan Annual Report 2012. The top 10 causes of death in Japan , 2012. View
  3. Review Team: LaBrecque DR, Abbas Z, Anania F, Ferenci P, et al. (2014) World Gastroenterology Organisation global guidelines: Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. J Clin Gastroenterol 48: 467-473. View
  4. Lavine JE, Schwimmer JB (2004) Nonalcoholic fatty liver disease in the pediatric population. Clin Liver Dis 8: 549-558, viii-ix. View
  5. Targher G (2007) Non-alcoholic fatty liver disease, the metabolic syndrome and the risk of cardiovascular disease: the plot thickens. Diabet Med 24: 1-6. View
  6. Cohen JC, Horton JD, Hobbs HH (2011) Human fatty liver disease: old questions and new insights. Science 332: 1519-1523. View
  7. Piedrahita JA, Zhang SH, Hagaman JR, Oliver PM, Maeda N (1992) Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc Natl Acad Sci U S A 89: 4471-4475. View
  8. Plump AS, Smith JD, Hayek T, Aalto-Setälä K, Walsh A, et al. (1992) Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 71: 343-353. View
  9. Coleman R, Hayek T, Keidar S, Aviram M (2006) A mouse model for human atherosclerosis: long-term histopathological study of lesion development in the aortic arch of apolipoprotein E-deficient (E0) mice. Acta Histochem 108: 415-424. View
  10. Meyrelles SS, Peotta VA, Pereira TM, Vasquez EC (2011) Endothelial dysfunction in the apolipoprotein E-deficient mouse: insights into the influence of diet, gender and aging. Lipids Health Dis 10: 211. View
  11. Stachowicz A, Olszanecki R, Suski M, Wiśniewska A, Totoń-Żurańska J, et al. (2014) Mitochondrial aldehyde dehydrogenase activation by Alda-1 inhibits atherosclerosis and attenuates hepatic steatosis in apolipoprotein E-knockout mice. J Am Heart Assoc 3: e001329. View
  12. Shibata MA, Shibata E, Fujioka S, Harada-Shiba M (2015) Atherosclerosis in apolipoprotein E-knockout mice as a model of human disease. Austin J Cardiovasc Dis Atherosclerosis 2: 1011.
Best viewed in Mozilla Firefox, Google Chrome, Safari, Above IE 9.0 version
Privacy Policy | Copyright & Permissions
Copyright © 2013-2024 Graphy Publications, All Rights Reserved.