Measuring Second Phase of Insulin Secretion by Components of Metabolic Syndrome

doi:10.15344/2394-1499/2015/113

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International Journal of Diabetes & Clinical Diagnosis Volume 2 (2015), Article ID 2:IJDCD-113, 6 pages
http://dx.doi.org/10.15344/2394-1499/2015/113

Research Article

Measuring Second Phase of Insulin Secretion by Components of Metabolic Syndrome

Yi-Tien Lin¹, Chung-Ze Wu², Wei-Cheng Lian³, Chun-Hsien Hsu⁴, Chang-Hsun Hsieh⁵, Dee Pei⁶, Yen-Lin Chen⁷ and Jiunn-Diann Lin^2*

¹Graduate Institute of Business Administration, Fu Jen Catholic University, Taipei, Taiwan
²Division of Endocrinology, Department of Internal Medicine, Shuang-Ho Hospital, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
³Division of Endocrinology and Metabolism, Department of Internal of Medicine, Buddhist Dalin Tzu Chi General Hospital and School of Medicine, Tzu Chi University, Taiwan
⁴Department of Family Medicine, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan
⁵Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical School
⁶Department of Internal Medicine, Cardinal Tien Hospital, Medical School, Catholic Fu Jen University, New Taipei City, Taiwan
⁷Department of Pathology, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan

Corresponding Author Details: Dr. Jiunn-Diann Lin, Department of Internal Medicine, Shuang Ho Hospital, No.291, Zhongzheng Rd., Zhonghe District, New Taipei City, 23561, Taiwan, Tel: +886-2-22490088; E-mail: jdlin1971@yahoo.com.tw

Received: 28 November 2015; Accepted: 29 December 2015; Published: 31 December 2015

Citation: Lin YT, Wu CZ, Lian WC, Hsu CH, Hsieh CH, et al. (2015) Measuring Second Phase of Insulin Secretion by Components of Metabolic Syndrome. Int J Diabetes Clin Diagn 2: 113. doi: http://dx.doi.org/10.15344/2394-1499/2015/113

Copyright: © 2015 Lin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Both decreased insulin sensitivity, and impaired insulin secretion are 2 major pathophyisologies for type 2 diabetes (T2DM). There are two phases of ISEC-the first (1^st ISEC) and second phase (2^nd ISEC). In this study, we tried to build an equation to predict 2^nd ISEC.

Totally, 82 subjects, including 15 with normal fasting glucose, 26 with pre-diabetes and 41 with T2DM were enrolled. They received a modified low dose graded glucose infusion (M-LDGGI). The M-LDGGI is a simplified version of Polonsky’s method. The results were interpreted as the slope of the changes of plasma insulin against the glucose levels. The slopes of these curves were regarded as the 2^nd ISEC.

If only metabolic syndrome (MetS) components were analyzed, the equation was built as the following: log (2^nd ISEC) = -2.400- 0.088 • (fasting plasma glucose, FPG + 0.072 • (body mass index, BMI). After fasting plasma insulin (FPI) was added , the equation was shown as the following: log (2^nd ISEC) = -2.316- 0.093˙FPG + 0.049 • BMI+ 0.434 • log(FPI). The second equation provided a greater accuracy to determine 2^nd ISEC than first one in the external validation group (r² = 0.545 vs r² = 0.423).

Using MetS components, 2^nd ISEC could be predicted with good accuracy. After adding FPI into the equation, the predictive power further increases. These equations could be widely used in daily practice and clinical settings.

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