References

1. Zhao HL, Houweling AH, Vanstone CA, Jew S, Trautwein EA, Duchateau GS, et al. (2011) Action of plant sterol intervention on sterol kinetics in hypercholesterolemic men with high versus low basal circulatory plant sterol concentrations. J Am Coll Nutr 30: 155-165 [CrossRef] [Google Scholar] [PubMed]
2. Genser B, Silbernagel G, De Backer G, Bruckert E, Carmena R, et al. (2012) Plant sterols and cardiovascular disease: a systematic review and meta-analysis. Eur Heart J 33:444-451 [CrossRef] [Google Scholar] [PubMed]
3. Bin Sayeed MS, Ameen SS (2015) beta-Sitosterol: A promising but orphan nutraceutical to fight against cancer. Nutr Cancer 67: 1214-1220 [CrossRef] [Google Scholar] [PubMed]
4. Sandqvist H, Bengtsson E (1931) The empirical formula of sitosterol. Berichte der Deutschen Chemischen Gesellschaft [Abteilung] B: Abhandlungen 64B: 2167–2171
5. Gillig JR, Heinz LJ, Kinnick MD, Lai YS, Morin JM, et al. (2006) MCH receptor antagonists. US Patent No. US7132456
6. Mathvink RJ, Edmondson SD, Weber AE (2007) Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes. US Patent No. US7208498
7. Ashton WT, Caldwell CG, Mathvink RJ, Ok HO, Reigle LB, et al. (2007) 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes. US Patent No. US7265128 [Google Scholar]
8. Duffy JL, Mathvink RJ, Weber AE, Xu J (2007) Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes. US Patent No. US7309714 [Google Scholar]
9. Sahoo SP, Koyama H, Miller DJ (2007) N-cyclohexylaminocarbonyl benzensulfonmide derivatives. US Patent No. US7319170 [Google Scholar]
10. Ho C-T, Bai N, Dong Z, Bode AM, Dushenkov S (2008) Bioactive compounds and methods of uses thereof.US Patent No. US7351739 [Google Scholar]
11. Alonso-Castro AJ, Zapata-Morales JR, González-Chavez MM, Carranza- Alvarez C, Hernandez-Benavides DM, et al. (20016) Pharmacological effects and toxicity of Costus pulverulentus C. Presl (Costaceae). J Ethnopharmacol 180: 124-130 [CrossRef] [Google Scholar] [PubMed]
12. Sudmoon R, Chaveerach A, Tanee T (2016) Analysis of genetics and chemical contents relation compared to commonly used Cissusquadrangularis L. and barcode markers of some Thailand Cissus species. Pak J Pharm Sci 29: 65-75 [Google Scholar] [PubMed]
13. Zhao H, Wang Y, Xu X, Ren H, Li L, et al. (2015) Detection of adulterated vegetable oils containing waste cooking oils based on the contents and ratios of cholesterol, β-sitosterol, and campesterol by gas chromatography/ mass spectrometry. J AOAC Int 98: 1645-1654 [CrossRef] [Google Scholar] [PubMed]
14. Mocan A, Vodnar DC, Vlase L, Crișan O, Gheldiu AM, et al. (2015) Phytochemical characterization of Veronica officinalis L., V. teucrium L. and V. orchidea Crantz from Romania and Their Antioxidant and Antimicrobial Properties. Int J Mol Sci 16: 21109-21127 [CrossRef] [Google Scholar] [PubMed]
15. Delgado-Zamarreno MM, Fernandez-Prieto C, Bustamante-Rangel M, Perez-Martin L (2016) Determination of tocopherols and sitosterols in seeds and nuts by QuEChERS-liquid chromatography. Food Chem192: 825-830 [CrossRef] [Google Scholar] [PubMed]
16. Teleszko M, Wojdylo A, Rudzinska M, Oszmianski J, Golis T (2015) Analysis of lipophilic and hydrophilic bioactive compounds content in sea buckthorn (Hippophaë rhamnoides L.) berries. J Agric Food Chem 63: 4120-4129 [CrossRef] [Google Scholar] [PubMed]
17. Esche R, Müller L, Engel KH (2013) Online LC-GC-based analysis of minor lipids in various tree nuts and peanuts. J Agric Food Chem 61: 11636- 11644 [CrossRef] [Google Scholar] [PubMed]
18. Ito N, Ohtsubo T, Kusu F, Hakamata H (2012) An ultra performance liquid chromatographic method for determining phytosterol uptake by Caco-2 cells. Anal Biochem 421: 86-91 [CrossRef] [Google Scholar] [PubMed]
19. Mendiara I, Domeno C, Nerin C (2012) Development of a fast sample treatment for the analysis of free and bonded sterols in human serum by LC-MS. J Sep Sci 35: 3308-3316 [CrossRef] [Google Scholar] [PubMed]
20. Wu AH, Ruan W, Todd J, Lynch KL (2014) Biological variation of β-sitosterol, campesterol, and lathosterol as cholesterol absorption and synthesis biomarkers. Clin Chim Acta 430: 43-47 [CrossRef] [Google Scholar] [PubMed]
21. Brindisi MC, Guiu B, Duvillard L, Athias A, Rollot F, et al. (2012) Liver fat content is associated with an increase in cholesterol synthesis independent of statin therapy use in patients with type 2 diabetes. Atherosclerosis 224: 465-468 [CrossRef] [Google Scholar] [PubMed]
22. Duchateau G, Cochrane B, Windebank S, Herudzinska J, Sanghera D, et al. (2012) Absolute oral bioavailability and metabolic turnover of β-sitosterol in healthy subjects. Drug Metab Dispos 40: 2026-2030 [CrossRef] [Google Scholar] [PubMed]
23. Lupattelli G, Siepi D, De Vuono S, Roscini AR, Crisanti F, et al. (2012) Cholesterol metabolism differs after statin therapy according to the type of hyperlipemia. Life Sci 90: 846-850 [CrossRef] [Google Scholar] [PubMed]
24. Husche C, Weingärtner O, Pettersson H, Vanmierlo T, Böhm M, et al. (2011) Validation of an isotope dilution gas chromatography-mass spectrometry method for analysis of 7-oxygenated campesterol and sitosterol in human serum. Chem Phys Lipids 164: 425-431 [CrossRef] [Google Scholar] [PubMed]
25. Zhang Z, Tan W, Hu Y, Li G (2011) Simultaneous determination of trace sterols in complicated biological samples by gas chromatographymass spectrometry coupled with extraction using β-sitosterol magnetic molecularly imprinted polymer beads. J Chromatogr A 1218: 4275-4283 [CrossRef] [Google Scholar] [PubMed]
26. Schott HF, Luister A, Husche C, Schafers HJ, Bohm M, et al. (2014) The relationships of phytosterols and oxyphytosterols in plasma and aortic valve cusps in patients with severe aortic stenosis. Biochem Biophys Res Commun 446: 805-810 [CrossRef] [Google Scholar] [PubMed]
27. Nghiem-Rao TH, Tunc I, Mavis AM, Cao Y, Polzin EM, et al. (2015) Kinetics of phytosterol metabolism in neonates receiving parenteral nutrition. Pediatr Res 78: 181-189 [CrossRef] [Google Scholar] [PubMed]
28. Delaney B, Stevens LA, Schmelzer W, Haworth J, McCurry S, et al. (2004) Oral absorption of phytosterols and emulsified phytosterols by Sprague- Dawley rats. J Nutr Biochem 15:289-295 [CrossRef] [Google Scholar] [PubMed]
29. Vanmierlo T, Weingartner O, van der Pol S, Husche C, Kerksiek A, et al. (2012) Dietary intake of plant sterols stably increases plant sterol levels in the murine brain. J Lipid Res 53: 726-735 [CrossRef] [Google Scholar] [PubMed]
30. Han NR, Kim HM, Jeong HJ (2014) The β-sitosterol attenuates atopic dermatitis-like skin lesions through down-regulation of TSLP. Exp Biol Med (Maywood) 239: 454-464 [CrossRef] [Google Scholar] [PubMed]
31. Ren Y, Yuan C, Deng Y, Kanagasabai R, Ninh TN, et al. (2015) Cytotoxic and natural killer cell stimulatory constituents of Phyllanthus songboiensis. Phytochemistry 111: 132-140 [CrossRef] [Google Scholar] [PubMed]
32. Vundru SS, Kale RK, Singh RP (2013) β-Sitosterol induces G1 arrest and causes depolarization of mitochondrial membrane potential in breast carcinoma MDA-MB-231 cells. BMC Complement Altern Med 13: 280 [CrossRef] [Google Scholar] [PubMed]
33. Zhang Z, Xing Y, Hu G, Xie S (2011) Antiproliferative effects mechanism of beta-sitosterol in hepatoma HepG2 cells (article in Chinese). Zhongguo Zhong Yao Za Zhi 36: 2145-2148 [Google Scholar] [PubMed]
34. Li XZ, Sun YL, Cao LQ, Li MJ (2016) Oxaliplatin-rapamycin combination was superiorto mono-drug in treatment of hepatocellular carcinoma both in vitro and in vivo. Neoplasma 63: 880-887 [CrossRef] [Google Scholar] [PubMed]
35. Sook SH, Lee HJ, Kim JH, Sohn EJ, Jung JH, et al. (2014) Reactive oxygen species-mediated activation of AMP-activated protein kinase and c-Jun N-terminal kinase plays a critical role in beta-sitosterol-induced apoptosis in multiple myeloma U266 cells. Phytother Res 28: 387-394 [CrossRef] [Google Scholar] [PubMed]
36. Zhang Z, Xing Y, Hu G, Xie S (2011) Antiproliferative effects mechanism of beta-sitosterol in hepatoma HepG2 cells [Article in Chinese]. Zhongguo Zhong Yao Za Zhi 36: 2145-2148 [Google Scholar] [PubMed]
37. Moon DO, Kim MO, Choi YH, Kim GY (2008) β-Sitosterol induces G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. Cancer Lett 264: 181-191 [CrossRef] [Google Scholar] [PubMed]
38. Zhang Y, Bao C, Mu Q, Chen J, Wang J, et al. (2016) Reversal of cisplatin resistance by inhibiting PI3K/Akt signal pathway in human lung cancer cells. Neoplasma 63: 362-370 [CrossRef] [Google Scholar] [PubMed]
39. Bildziukevich U, Vida N, Rárová L, Kolář M, Šaman D, et al. (2015) Polyamine derivatives of betulinic acid and β-sitosterol: A comparative investigation. Steroids 100: 27-35 [CrossRef] [Google Scholar] [PubMed]
40. Ovesna Z, Vachalkova A, Horvathova K (2004) Taraxasterol and betasitosterol: new naturally compounds with chemoprotective/chemopreventive effects. Neoplasma 51: 407-414 [Google Scholar] [PubMed]
41. Grattan BJ (2013) Plant Sterols as Anticancer Nutrients: Evidence for Their Role in Breast Cancer. Nutrients 5: 359-387 [CrossRef] [Google Scholar] [PubMed]
42. Eid SY, El-Readi MZ, Eldin EE, Fatani SH, Wink M (2013) Influence of combinations of digitonin with selected phenolics, terpenoids, and alkaloids on the expression and activity of P-glycoprotein in leukaemia and colon cancer cells. Phytomedicine 21: 47-61 [CrossRef] [Google Scholar] [PubMed]
43. Ju YH, Clausen LM, Allred KF, Almada AL, Helferich WG, et al. (2004) β-Sitosterol, β-sitosterol glucoside, and a mixture of β-sitosterol and β-sitosterol glucoside modulate the growth of estrogen-responsive breast cancer cells in vitro and in ovariectomized athymic mice. J Nutr 134: 1145- 1151 [CrossRef] [Google Scholar] [PubMed]
44. Awad AB, Barta SL, Fink CS, Bradford PG (2008) β-Sitosterol enhances tamoxifen effectiveness on breast cancer cells by affecting ceramide metabolism. Mol Nutr Food Res 52: 419-426 [CrossRef] [Google Scholar] [PubMed]
45. Awad AB, Downie A, Fink CS, Kim U (2008) Dietary phytosterol inhibits the growth and metastasis of MDA-MB-231 human breast cancer cells grown in SCID mice. Anticancer Res 20: 821-824 [Google Scholar] [PubMed]
46. Awad AB, Fink CS, Williams H, Kim U (2001) In vitro and in vivo (SCID mice) effects of phytosterols on the growth and dissemination of human prostate cancer PC-3 cells. Eur J Cancer Prev 10: 507-513 [CrossRef] [Google Scholar] [PubMed]
47. Baskar AA, Al Numair KS, Gabriel Paulraj M, Alsaif MA, Muamar MA, et al. (2012) β-sitosterol prevents lipid peroxidation and improves antioxidant status and histoarchitecture in rats with 1,2-dimethylhydrazine-induced colon cancer. J Med Food 15: 335-343 [CrossRef] [Google Scholar] [PubMed]
48. Sun QY, Qu CH, Liu JQ, Zhang P, Yao J (2017) Down-regulated expression of Tim-3 promotes invasion and metastasis of colorectal cancer cells. Neoplasma 64: 101-107 [CrossRef] [Google Scholar] [PubMed]
49. Xu M, Kuang Y, Wang M, Han X, Yang Q (2017) A microRNA expression signature as a predictor of survival for colon adenocarcinoma. Neoplasma 64: 56-64 [CrossRef] [Google Scholar] [PubMed]
50. He L, Deng HY, C Wang X (2017) Decreased expression of MS4A12 inhibits differentiation and predicts early stage survival in colon cancer. Neoplasma 64: 65-73 [CrossRef] [Google Scholar] [PubMed]
51. Imanaka H1, Koide H, Shimizu K, Asai T, Kinouchi Shimizu N, et al. (2008) Chemoprevention of tumor metastasis by liposomal β-sitosterol intake. Biol Pharm Bull 31: 400-404 [CrossRef] [Google Scholar] [PubMed]
52. Deschner EE, Cohen BI, Raicht RF (1982) The kinetics of the protective effect of β-sitosterol against MNU-induced colonic neoplasia. J Cancer Res Clin Oncol 103: 49-54 [CrossRef] [Google Scholar] [PubMed]
53. Muti P, Awad AB, Schünemann H, Fink CS, Hovey K, et al. (2003) A plant food-based diet modifies the serum β-sitosterol concentration in hyperandrogenic postmenopausal women. J Nutr 133: 4252-4255 [CrossRef] [Google Scholar] [PubMed]
54. Li JH, Awad AB, Fink CS, Wu YW, Trevisan M, et al. (2001) Measurement variability of plasma β-sitosterol and campesterol, two new biomarkers for cancer prevention. Eur J Cancer Prev 10: 245-249 [CrossRef] [Google Scholar] [PubMed]
55. Peuchant E, Salles C, Jensen R (1987) Relationship between fecal neutral steroid concentrations and malignancy in colon cells. Cancer 60: 994-999 [CrossRef] [Google Scholar] [PubMed]