Profile
International Journal of Clinical Pharmacology & Pharmacotherapy Volume 1 (2016), Article ID 1:IJCPP-101, 4 pages
https://doi.org/10.15344/2456-3501/2016/101
Research Article
Study the Nephro-protective Effects of Losartan on Rats

Hosny Ahmed Elewa

Department of Clinical and hospital Pharmacy, Faculty of Pharmacy, Taibah University, Kingdom of Saudi Arabia
Dr. Hosny Ahmed Elewa, Department of Clinical and hospital Pharmacy, Faculty of Pharmacy, Taibah University, Kingdom of Saudi Arabia; E-mail: hosnyelewa1960@yahoo.com
14 November 2015; 18 January 2016; 20 January 2016
Elewa HA (2016) Study the Nephro-protective Effects of Losartan on Rats. Int J Clin Pharmacol Pharmacother 1: 101. doi: https://doi.org/10.15344/2456-3501/2016/101

References

  1. Gradman AH, Arcuri KE, Goldberg AI, Ikeda LS, Nelson EB, et al. (1995) A randomized, placebo-controlled, double-blind, parallel study of various doses of losartan potassium compared with enalapril maleate in patients with essential hypertension. Hypertension 25: 1345-1350 [CrossRef] [Google Scholar] [PubMed]
  2. Brenner BM, Cooper ME, de Zeeuw D, Keane WF, Mitch WE, et al. (2001) Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 345: 861-869 [CrossRef] [Google Scholar] [PubMed]
  3. Guo ZX, Qiu MC (2003) [Losartan downregulates the expression of transforming growth factor beta type I and type II receptors in kidney of diabetic rat]. Zhonghua Nei Ke Za Zhi 42: 403-408 [Google Scholar] [PubMed]
  4. Kopple JD, Ding H, Letoha A, Ivanyi B, Qing DP (2002) L-carnitine ameliorates gentamicin-induced renal injury in rats. Nephrol Dial Transplant. 17: 2122-2131 [CrossRef] [Google Scholar] [PubMed]
  5. Sakthi SP, Vadivu R, Jayshree N (2010) Hypolipidaemic and Renoprotective study on the Ethanolic & Aqueous extracts of leaves of Ravenala madagascariensis Sonn., on alloxan induced diabetic rats. Int J Pharm Sci 2: 44-50 [View]
  6. Takashi A, Hiromu T, Yuka I, Hiroko M (2002) Antibacterial activity of Extracts prepared from tropical and subtropical plants on methicillin–resistant Staphylococcus Aureus. J Health Science 48: 273-276 [CrossRef] [Google Scholar]
  7. Cau J, Favreau F, Tillement JP, Lerman LO, Hauet T (2008) Trimetazidine reduces early and long-term effects of experimental renal warm ischemia: a dose effect study. J Vasc Surg 47: 852-860 [CrossRef] [Google Scholar] [PubMed]
  8. Fawcett jK, Scott JE (1960) A rapid and precise method for the determination of urea. J Clin Path 13: 156-159 [CrossRef] [Google Scholar] [PubMed]
  9. Bartels H, Bohmer M (1971) [Micro-determination of creatinine]. Clin Chim Acta 32: 81-85 [CrossRef] [PubMed]
  10. Kelly DJ, Skinner SL, Gilbert RE, Cox AJ, Cooper ME, et al. (2000) Differential effects of bosentan and valsartan with respect to progressive diabetic renal pathology in the transgenic (mRen- 2)27-rat model. Kidney Int 57: 1882–1894
  11. Suzuki S, Takamura S, Yoshida J, Shinzawa Y, Niwa O, et al. (1995) Comparison of gentamicin nephrotoxicity between rats and mice. Camp Biochem Physiol Pharmacol Toxical Endocrinal 112: 15-28 [CrossRef] [Google Scholar] [PubMed]
  12. Abdel-Raheem IT, EL-Sherbiny G, Taye A (2010) Green tea ameliorates renal oxidative damage induced by gentamicin in rats. Pak J Pharm Sci 23: 21-28 [Google Scholar] [PubMed]
  13. Naidu MU, Shifow AA, Kumar KV, Ratnakar KS (2000) Ginkgo biloba extract ameliorates gentamicin-induced nephrotoxicity in rats. Phytomedicine. 7: 191- 197 [CrossRef] [Google Scholar] [PubMed]
  14. Sandhya P, Varalakshmi P (1997) Effect of lipoic acid administration on gentamicin-induced lipid peroxidation in rats. J Appl Toxicol 17: 405-408 [CrossRef] [Google Scholar] [PubMed]
  15. Heeba GH (2011) Angiotensin II receptor blocker, losartan, ameliorates gentamicin-induced oxidative stress and nephrotoxicity in rats. Pharmacology 87: 232-240 [CrossRef] [Google Scholar] [PubMed]
  16. Hall A, Karplus PA, Poole LB (2009) Typical 2-Cys peroxiredoxins--structures, mechanisms and functions. FEBS J 276: 2469-2477 [CrossRef] [Google Scholar] [PubMed]
  17. Herrera M, Silva GB, Garvin JL (2010) Angiotensin II stimulates thick ascending limb superoxide production via protein kinase C(α)-dependent NADPH oxidase activation. J Biol Chem 285: 21323-21328 [CrossRef] [Google Scholar] [PubMed]