Table 3: Summary of Commercially Available Tests.
(data collected from www.carismolecularintelliegence.com; www.foundationone.com; www.paradigmdx.com; www.oncodna.com)
Caris Molecular Intelligence® FoundationOne® PCDx™ OncoDEEP™
Description of Services performed
Approach Multiplatform Single platform Multiplatform Multiplatform
Immunohistochemistry Yes No Limited Limited
RNA fusion Yes No No No
RNA expression No No No Yes
Pyrosequencing Yes No Yes No
Next generation sequencing Yes Yes Yes Yes
Gene copy number variation Yes (442 genes) Yes Yes (26 genes) Yes (53 genes)
Tumor mutational load Yes Yes No Yes
Sequencing technology Illumina Illumina Ion Torrent Ion Torrent
Number of genes 592 315 131 150
Type of Sequencing Full exon Full exon Hotspot only Hotspot only
Depth of Coverage (ave) 750x 500x 5000x 1000x
External Quality Certifications and Accreditation
CLIA
CAP
NYSDOH
ISO15189:2012
Other considerations
Experience >110,000 cases > 90,000 cases Not reported >2,000 cases
Laboratory Location Phoenix, AZ, USA Cambridge, MA, USA Phoenix, AZ, USA Gosselies, Belgium
Turnaround Time 10-14 calendar days 14 calendar days 4-5 working days 10 working days