| Caris Molecular Intelligence® | FoundationOne® | PCDx™ | OncoDEEP™ |
Description of Services performed |
Approach | Multiplatform | Single platform | Multiplatform | Multiplatform |
Immunohistochemistry | Yes | No | Limited | Limited |
RNA fusion | Yes | No | No | No |
RNA expression | No | No | No | Yes |
Pyrosequencing | Yes | No | Yes | No |
Next generation sequencing | Yes | Yes | Yes | Yes |
Gene copy number variation | Yes (442 genes) | Yes | Yes (26 genes) | Yes (53 genes) |
Tumor mutational load | Yes | Yes | No | Yes |
Sequencing technology | Illumina | Illumina | Ion Torrent | Ion Torrent |
Number of genes | 592 | 315 | 131 | 150 |
Type of Sequencing | Full exon | Full exon | Hotspot only | Hotspot only |
Depth of Coverage (ave) | 750x | 500x | 5000x | 1000x |
External Quality Certifications and Accreditation |
CLIA | ✔ | ✔ | ✔ | ✖ |
CAP | ✔ | ✔ | ✔ | ✔ |
NYSDOH | ✔ | ✔ | ✔ | ✔ |
ISO15189:2012 | ✔ | ✖ | ✖ | ✔ |
Other considerations |
Experience | >110,000 cases | > 90,000 cases | Not reported | >2,000 cases |
Laboratory Location | Phoenix, AZ, USA | Cambridge, MA, USA | Phoenix, AZ, USA | Gosselies, Belgium |
Turnaround Time | 10-14 calendar days | 14 calendar days | 4-5 working days | 10 working days |