Figure 1: Natural History of Frailty.
Humans are the most vulnerable in their infant and old age. It gets stronger as it develops. Between the teens and twenties are the hardest time to die. After that, aging begins, and gradually becomes vulnerable until death. If aging progresses gradually, the boundary between a completely healthy state and an asymptomatic state (but frailty is processing) is unclear. Also the boundary where frailty manifests itself is relatively ambiguous. Death occurs when frailty fails to push back life-threatening event.
Humans are the most vulnerable in their infant and old age. It gets stronger as it develops. Between the teens and twenties are the hardest time to die. After that, aging begins, and gradually becomes vulnerable until death. If aging progresses gradually, the boundary between a completely healthy state and an asymptomatic state (but frailty is processing) is unclear. Also the boundary where frailty manifests itself is relatively ambiguous. Death occurs when frailty fails to push back life-threatening event.
