Table 3: Pharmacokinetic parameters of LORATADINE following administration of single oral dose of Loratadine 10mg Rapid Dissolve Tablets (Reference product) to 24 Volunteers.
Reference
Subject Tmax Cmax AUClast AUCINF Lambda_z t1/2 MRTINF
A 1.5 1.34148 20.2811 25.9565 0.02375 29.1854 45.2952
B 0.333 2.83813 11.3876 12.9661 0.03554 19.501 31.5755
C 0.75 1.73774 34.4088 37.7849 0.03137 22.0945 30.3295
D 0.75 4.40916 26.0494 27.5807 0.03918 17.6895 21.7585
E 0.5 7.60105 37.3893 38.9734 0.04159 16.6681 19.9755
F 2.5 7.11504 60.3607 66.2837 0.03022 22.9397 29.7998
G 1.5 2.77739 36.3754 47.9384 0.02382 29.105 47.6117
H 2 5.24442 49.9299 56.233 0.0374 18.535 27.6745
I 1 6.87602 46.1556 51.0214 0.04125 16.8035 26.9378
J 1 4.31205 27.8765 33.1211 0.03476 19.9412 34.255
K 3 4.10985 53.6978 62.4771 0.02974 23.3089 36.0146
L 1.5 5.7906 33.6403 38.2732 0.03034 22.845 28.9835
M 1.5 7.74371 53.8507 60.4603 0.03054 22.6951 32.1991
N 1.5 7.00874 64.586 66.8072 0.04154 16.688 21.6528
O 1 7.41284 67.3895 69.3063 0.04221 16.4232 22.4599
P 0.75 8.52161 50.3561 52.0271 0.04578 15.1411 24.0349
Q 3 5.25433 63.5424 69.623 0.03538 19.5922 26.1669
R 1.5 3.41738 25.7631 27.4308 0.03498 19.8133 22.3605
S 0.75 3.82562 23.2236 26.2029 0.03495 19.8308 30.4172
T 0.333 7.18506 39.3398 47.18 0.02648 26.1741 40.1723
U 1 4.41894 89.1306 101.424 0.02984 23.2277 32.9004
V 3 6.09665 79.4598 88.1425 0.03605 19.2258 28.7707
W 2 7.14766 81.289 85.8432 0.04448 15.5849 23.0244
X 1.5 7.19241 35.3212 39.8062 0.03643 19.0257 27.3371
Mean 1.42358 5.39075 46.2835 51.3693 0.0349 20.5016 29.6545
SD 0.80982 2.04836 20.665 22.1563 0.00614 3.88311 7.19818
CV% 56.8861 37.9978 44.6488 43.1315 17.5803 18.9405 24.2735
Min 0.333 1.34148 11.3876 12.9661 0.02375 15.1411 19.9755
Max 3 8.52161 89.1306 101.424 0.04578 29.1854 47.6117
Median 1.5 5.52247 42.7477 49.4799 0.03518 19.7027 28.8771