Table 3: Pharmacokinetic parameters of LORATADINE following administration of single oral dose of Loratadine 10mg Rapid Dissolve Tablets (Reference product) to 24 Volunteers.
Reference |
Subject | Tmax | Cmax | AUClast | AUCINF | Lambda_z | t1/2 | MRTINF |
A | 1.5 | 1.34148 | 20.2811 | 25.9565 | 0.02375 | 29.1854 | 45.2952 |
B | 0.333 | 2.83813 | 11.3876 | 12.9661 | 0.03554 | 19.501 | 31.5755 |
C | 0.75 | 1.73774 | 34.4088 | 37.7849 | 0.03137 | 22.0945 | 30.3295 |
D | 0.75 | 4.40916 | 26.0494 | 27.5807 | 0.03918 | 17.6895 | 21.7585 |
E | 0.5 | 7.60105 | 37.3893 | 38.9734 | 0.04159 | 16.6681 | 19.9755 |
F | 2.5 | 7.11504 | 60.3607 | 66.2837 | 0.03022 | 22.9397 | 29.7998 |
G | 1.5 | 2.77739 | 36.3754 | 47.9384 | 0.02382 | 29.105 | 47.6117 |
H | 2 | 5.24442 | 49.9299 | 56.233 | 0.0374 | 18.535 | 27.6745 |
I | 1 | 6.87602 | 46.1556 | 51.0214 | 0.04125 | 16.8035 | 26.9378 |
J | 1 | 4.31205 | 27.8765 | 33.1211 | 0.03476 | 19.9412 | 34.255 |
K | 3 | 4.10985 | 53.6978 | 62.4771 | 0.02974 | 23.3089 | 36.0146 |
L | 1.5 | 5.7906 | 33.6403 | 38.2732 | 0.03034 | 22.845 | 28.9835 |
M | 1.5 | 7.74371 | 53.8507 | 60.4603 | 0.03054 | 22.6951 | 32.1991 |
N | 1.5 | 7.00874 | 64.586 | 66.8072 | 0.04154 | 16.688 | 21.6528 |
O | 1 | 7.41284 | 67.3895 | 69.3063 | 0.04221 | 16.4232 | 22.4599 |
P | 0.75 | 8.52161 | 50.3561 | 52.0271 | 0.04578 | 15.1411 | 24.0349 |
Q | 3 | 5.25433 | 63.5424 | 69.623 | 0.03538 | 19.5922 | 26.1669 |
R | 1.5 | 3.41738 | 25.7631 | 27.4308 | 0.03498 | 19.8133 | 22.3605 |
S | 0.75 | 3.82562 | 23.2236 | 26.2029 | 0.03495 | 19.8308 | 30.4172 |
T | 0.333 | 7.18506 | 39.3398 | 47.18 | 0.02648 | 26.1741 | 40.1723 |
U | 1 | 4.41894 | 89.1306 | 101.424 | 0.02984 | 23.2277 | 32.9004 |
V | 3 | 6.09665 | 79.4598 | 88.1425 | 0.03605 | 19.2258 | 28.7707 |
W | 2 | 7.14766 | 81.289 | 85.8432 | 0.04448 | 15.5849 | 23.0244 |
X | 1.5 | 7.19241 | 35.3212 | 39.8062 | 0.03643 | 19.0257 | 27.3371 |
Mean | 1.42358 | 5.39075 | 46.2835 | 51.3693 | 0.0349 | 20.5016 | 29.6545 |
SD | 0.80982 | 2.04836 | 20.665 | 22.1563 | 0.00614 | 3.88311 | 7.19818 |
CV% | 56.8861 | 37.9978 | 44.6488 | 43.1315 | 17.5803 | 18.9405 | 24.2735 |
Min | 0.333 | 1.34148 | 11.3876 | 12.9661 | 0.02375 | 15.1411 | 19.9755 |
Max | 3 | 8.52161 | 89.1306 | 101.424 | 0.04578 | 29.1854 | 47.6117 |
Median | 1.5 | 5.52247 | 42.7477 | 49.4799 | 0.03518 | 19.7027 | 28.8771 |