Overview of Malignant Solid Tumors in Neonates : Table 1

Table 1: Tumors in Neonates and Associated Genetic Abnormalities and Syndromes.

Tumor	Incidence in Neonates	Clinical Findings	Genetic Alterations and Associated Syndromes and Conditions
Sacrococcygeal Teratomas	35 – 60% of all teratomas	Hydrops fetalis Large sacral mass Anorectal malformation	Currarino Triad Klinefelter Syndrome
Neuroblastoma	20% of all NBL	Hepatomegaly Skin nodules Heterochromia iridis Horner Syndrome	ALK gene mutations PHOX2B gene mutations Hypoventilation syndrome Hirschsprung’s disease
Soft Tissue Tumors, Sarcomas	10-15 % of all STT	Abdominal mass Hematuria Soft Tissue mass	Li-Fraumeni
Disseminated Fibromatosis	?	Visceral Tumors	PDGFRB gene mutations
Infantile Fibrosarcoma	?	Soft tissue tumors in the extremities	ETV6 and NTRK3 gene mutations
ATRT of the Brain	Very Rare?	Brain mass Hydrocephalus	INI1 mutation
Subependymal Giant Cell Astrocytoma (SEGA)	2.2% are congenital	Brain mass Hydrocephalus	Tuberous Sclerosis
Hepatoblastoma	10% of all HBL	Abdominal Mass	Beckwith-Wiedemann Li-Fraumeni FAP Trisomy 18
Wilms Tumor	0.2% of all WT	Abdominal mass Hypertension Hematuria	Beckwith-Wiedemann WAGR Denys-Drash Simpson-Golabi-Behmel Hemihypertrophy Soto’s Syndrome
Malignant Rhabdoid Tumor of the Kidney (MRTK)		Abdominal mass Hypertension Hematuria	INI1 mutation