Table 2: GRADE table example in diagnostic tests (prognostic value of amplitude integrated electroencephalogram at 24 hours of life, newborns treated with hypothermia).
*aEEG: amplitude integrated electroencephalogram; +LHR: positve likelihood ratio. –LHR; : negative likelihood ratio. TP: true positive; TN: true negative; FP: false positive; FN false negative.

Outcome: Death or moderate/severe disability.

Limitations
Outcome No of studies (patients) Study type Methodological limitations Indirectness Inconsistency Imprecision Publication bias Final quality
Hypothermia: Pre test probability 47.88%
aEEG 24 hours of life 3 (65) Cohorts Yes -1 No No Yes (-1) No +2 (Magnitude effect) HIGH

Outcome: Death or moderate/severe disability .

Outcome Positive Post test (CI 95%) Negative Post test (CI 95%) +LHR (CI 95%) -LHR (CI 95%) TP (critical)* TN (critical) FP (critical) FN (critical) Indeter-minates Complications Costs
aEEG 24 hours 76,7% (64,4 to 84,5%) 7,6% (1,8 to 27,4%) 3,58 (2,15 to 5,95) 0,09 (0,02 to 0,41) 46 39 14 2 0 No Low