Table 2: Clinical situations should be suspected hepatitis E (request IgG anti-HEV, IgM anti-HEV and /or HEV RNA).

Acute hepatitis with negative markers for hepatitis A, B and C

Acute hepatitis with any risk factors (travel to endemic areas, contact with animals, “unusual” food consumption...) independently of other markers of viral hepatitis

Liver failure or decomposition in chronic liver disease

Drug-induced hepatitis

Autoimmune hepatitis

Chronic liver disease of unknown etiology in immune compromised patients