Table 3: IC₅₀ of ovarian cancer cell with and without overexpression and downregulation of Akt subsequent to treatment with cisplatinum . Cytotoxicity was determined by MTT- assay. Statistically significant differences (*= p<0.005) exist between A2780, A2780 AKT+ and A2780 AKT- and between A2780cis and A2780cis AKT-. All data were previously published in “Oncology Reports” [72] and is reprinted by permission of Spandidos Publications ©2012.