Table 2:
Frequencies of specific mutations in PIK3CA. These mutations usually occur within two hotspot-areas within the helical domain (encoded by exon 9) and the kinase domain (encoded by exon 20). Data are according to COSMIC database.
Exon
Amino Acid Change
Nucleotide Change
Frequency Among PIK3CAMutated Ovarian Cancer
9
E542K
1624G>A
10.2%
E545K
1633G>A
12.6%
E545A
1634A>C
12.6%
Q546K
1636C>A
1.8%
20
H1047R
3140A>G
41.4%
H1047L
3140A>T
2.8%