Table 1: Comparison of the main characteristics of stem cell studies in women with urinary incontinence.
Reference Year of Publication Study Design n Number of Stem Cells Injection Site Outcomes Followup, m
[1] Sebe 2012 Randomized 3 doses 12 Myoblasts
Group 1: 1x107
Group 2: 2.5x107
Group 3: 5x107
Sphincter 25%, cures
83%, improvement
(dose-independent)
12
[2] Carr 2013 Randomized 2 doses 38 Myoblasts
Low dose: 1-16x106
High dose: 32-128x106
2 sphincter areas, cystoscope 84% 2 doses 88.9%, improvement high dose
61.5%, improvement, low dose
5.3% worsen
18
[3] Mittelberguer 2007 Prospective interventional + electrical stimulation 123 Myoblasts 2.8x107
Fibroblasts 3.8x107
Rhabdosphincter and submucosa, ultrasound guided 79%, dry
13%, improvement
9%, mild improvement
12
[4] Mittelberguer 2007 2008 Prospective interventional + electrical stimulation 20 Myoblasts 1-3x107
Fibroblasts 1.4-6.06x107
Rhabdosphincter and submucosa, ultrasound-guided 89%, dry
11%, improvement
24
[5] Lee 2010 Prospective interventional 39 Umbilical cord 4.3-1.9x108 Ureterovesical juncture, ultrasound-guided 72.2%, improvement 12
[6] Stangel 2013 Prospective interventional 16 Myoblasts 0.6-25x106 Rhabdosphincter, cystoscope 50%, dry
25%, improvements
25%, no improvement
24
[7] Carr 2008 Prospective interventional 8 Myoblasts 18-22x106 Rhabdosphincter, cystoscope (3 patients, reinjection at 3 months) 12.5%, dry
62.5%, improvement
10
[8] Blaganje 2012 Prospective interventional + electrical stimulation 38 Myoblasts 1x106-5x107 Rhabdosphincter, ultrasoundguided (26 injections) 13.5%, cured
78.4%, improvement
8%, equal
1.5
[9] Surcel 2012 Prospective interventional 8 Myoblasts Middle urethra, ultrasoundguided - 12