Reference Year of Publication | Study Design | n | Number of Stem Cells | Injection Site | Outcomes | Followup, m |
[1] Sebe 2012 | Randomized 3 doses | 12 | Myoblasts Group 1: 1x107 Group 2: 2.5x107 Group 3: 5x107 | Sphincter | 25%, cures 83%, improvement (dose-independent) | 12 |
[2] Carr 2013 | Randomized 2 doses | 38 | Myoblasts Low dose: 1-16x106 High dose: 32-128x106 | 2 sphincter areas, cystoscope 84% 2 doses | 88.9%, improvement high dose 61.5%, improvement, low dose 5.3% worsen | 18 |
[3] Mittelberguer 2007 | Prospective interventional + electrical stimulation | 123 | Myoblasts 2.8x107 Fibroblasts 3.8x107 | Rhabdosphincter and submucosa, ultrasound guided | 79%, dry 13%, improvement 9%, mild improvement | 12 |
[4] Mittelberguer 2007 2008 | Prospective interventional + electrical stimulation | 20 | Myoblasts 1-3x107 Fibroblasts 1.4-6.06x107 | Rhabdosphincter and submucosa, ultrasound-guided | 89%, dry 11%, improvement | 24 |
[5] Lee 2010 | Prospective interventional | 39 | Umbilical cord 4.3-1.9x108 | Ureterovesical juncture, ultrasound-guided | 72.2%, improvement | 12 |
[6] Stangel 2013 | Prospective interventional | 16 | Myoblasts 0.6-25x106 | Rhabdosphincter, cystoscope | 50%, dry 25%, improvements 25%, no improvement | 24 |
[7] Carr 2008 | Prospective interventional | 8 | Myoblasts 18-22x106 | Rhabdosphincter, cystoscope (3 patients, reinjection at 3 months) | 12.5%, dry 62.5%, improvement | 10 |
[8] Blaganje 2012 | Prospective interventional + electrical stimulation | 38 | Myoblasts 1x106-5x107 | Rhabdosphincter, ultrasoundguided (26 injections) | 13.5%, cured 78.4%, improvement 8%, equal | 1.5 |
[9] Surcel 2012 | Prospective interventional | 8 | Myoblasts | Middle urethra, ultrasoundguided | - | 12 |