| Lira + IGla | MII | |||||
| Mean ± SD (n) | Mean change from baseline (95% CI) p-value, (n) | Mean ± SD (n) | Mean change from baseline (95% CI) p-value (n) | |||
| Baseline | 3 months | Baseline | 3 months | |||
| Body weight (kg) | 79.1 ± 14.4 (20) | 73.6 ± 12.7 (15) | 2.5 (0.6–4.4) <0.05 (15) | 70.2 ± 17.5 (10) | 73.9 ± 15.7 (8) | 0.1 (−2.8–2.9) 0.95 (8) |
| BMI (kg/m2) | 27.3 ± 4.7 (20) | 25.4 ± 3.6 (15) | 0.9 (0.2–1.6) <0.05 (15) | 26.1 ± 5.0 (10) | 27.3 ± 5.2 (8) | 0.0 (−1–1.1) 0.92 (8) |
| Plasma glucose (mg/dL) | 253.1 ± 145.3 (20) | 142.3 ± 45.5 (16) | 74.5 (49.5–99.5) <0.001 (16) | 291.7 ± 228.8 (10) | 145.7 ± 49.6 (10) | 146.0 (−27.6–319.6) 0.09(10) |
| HbA1c (%)[mmol/mol] | 10.8 ± 1.7 [94.5 ± 18.6] (20) | 6.8 ± 0.9 [50.8 ± 9.8] (16) | 3.9 (3.1–4.8) [19.1(10.4–28.9)] <0.001 (16) | 10.9 ± 1.6 [95.6 ± 17.5] (10) | 6.7 ± 0.8 [49.7 ± 8.7] (10) | 4.2 (2.7–5.7) [22.4(6.0–38.8)] <0.001 (10) |
| HDL-C (mg/dL) | 46.8 ± 11.7 (18) | 50.6 ± 9.8 (16) | 1.6 (−4–7.1) 0.55 (14) | 54.8 ± 26.8 (10) | 56.7 ± 24.0 (10) | 1.9 (−4.2–8) 0.50(10) |
| LDL-C (mg/dL) | 144.7 ± 43.2 (18) | 124.7 ± 32.6 (16) | 27.2 (14.6–39.8) <0.001 (14) | 127.6 ± 57.6 (10) | 101.9 ± 41.4 (10) | 25.7 (0.3–51.1) <0.05 (10) |
| TG (mg/dL) | 295.0 ± 337.8 (18) | 244.2 ± 263.6 (16) | 40.5 (−12.6–93.6) 0.12 (14) | 186.4 ± 101.9 (10) | 157.2 ± 111.4 (10) | 29.2 (−18.6–77.0) 0.20 (10) |
| AST (IU/L) | 31.7 ± 21.3 (20) | 21.1 ± 8.2 (16) | 8 (−0.9–16.9) 0.08(16) | 25.7 ± 24.7 (10) | 24.6 ± 16.4 (10) | 1.1 (−5.7–7.9) 0.72 (10) |
| ALT (IU/L) | 43.9 ± 28.3 (20) | 24.0 ± 8.7 (16) | 16.8 (2.3–31.3) <0.05 (16) | 28.6 ± 27.4 (10) | 24.7 ± 15.7 (10) | 3.9 (−8.8–16.6) 0.50 (10) |