Figure 1: In diabetes and neurodegenerative diseases nutritional interventions are required to activate the anti-aging gene Sirt 1 and prevent defective liver lipid metabolism (NAFLD) and amyloid beta metabolism. Diets that are low in fat such as very low carbohydrate diets activate the calorie sensitive gene Sirt 1 with glucose metabolism connected to accelerated hepatic lipid/amyloid beta metabolism in diabetes and neurodegenerative diseases.