Figure 2: Proposed pathogenesis of Hemoglobin Disruptions and T cell Dysregulation. Denoted in this image is the process of SARS-Cov-2 proteins: ORF8, ORF10, orf1ab, ORF3a interacting with heme component of the hemoglobin disrupting effective tissue oxygen delivery. Represented in this image are CD8 T cells that contribute to cytotoxicity, TNF and interferon (INF) release and chemotaxis. Cell-surface interaction between the T cells and the infected cell by the Fas ligand on the infected cell binding to the Fas molecule that is expressed on the T cell leads to apoptosis.