Indirect Effect on Cardiovascular Function |
Mild hypertension |
Narrowed pulse pressure |
High serum concentrations of cholesterol |
High serum concentrations of creatinine kinase (specifically CK-MM) |
Pericardial effusions |
Non-Pitting edema (myxedema) |
Cardiac arrhythmias (Torsade de pointes) |
Accelerated atherosclerosis and coronary artery disease |
Increased carotid intimal thickening |
Impaired endothelial-dependent vasodilation |
Direct Effect on Cardiovascular Function |
Increase systemic vascular resistance |
Decrease heart rate |
Decrease ejection fraction |
Decrease cardiac output |
Increase isovolumetric relaxation time |
Decrease blood volume |