Table 1: RA Clinical Characteristics for Cancer and No Cancer Cohorts.
Percentages were calculated based on the number of patients with data available on the measure. ACPA: anti-citrullinated peptide antibody, BMI: body mass index, CAD: coronary artery disease, COPD: chronic obstructive pulmonary disease, CRP: C reactive protein, CVD: cardiovascular disease, DMARD: disease modifying anti-rheumatic drugs, ESR: erythrocyte sedimentation rate, MI: myocardial infarction, RF: rheumatoid factor, SENS: simple erosion narrowing score.
**C reactive protein >10 mg/L. is associated with MI [11].
***Erythrocyte sedimentation rate >42mm/hr. is associated with MI and ischemic stroke risk [11,12].
With Cancer Without Cancer p value
Total Number of Patients 56 445
Mean Age ±STD (in years) 67.4±11.3 64.3±15.1 NS
Number of women (%) 87.5% 87.8% NS
Race/Ethnicity
White 9.5% 69.6% NS
Black 88.0% 88.3% NS
Native American - 0.2% NS
Asian Pacific Islander - 0.7% NS
Other 2.3% 3.7% NS
Hispanics 8.1% 8.3% NS
Other Characteristics
Non-smoker 68.2% 70.8% NS
Ever smoker 31.8% 29.2% NS
BMI (mean ± STD) 28.1±5.7 29.0±7.7 NS
BMI ≥ 30 Kg/m2 27.5% 38.4% NS
BMI <20 kgm2 3.9% 8% NS
Asthma 14% 16.9% NS
COPD 17.6% 11.1% NS
Diabetes mellitus 39.2% 27.4% NS
Hypertension 75% 65.7% NS
Hyperlipidemia 45% 40.5% NS
CAD or MI 20.4% 19.5% NS
Cerebrovascular accident 8.1% 9.9% NS
Chronic kidney disease 18% 11.3% NS
Venous thromboembolism 16.3% 12.5% NS
Atrial fibrillation 12% 8% NS
Congestive heart failure 19.6% 14.7% NS
At least 1 CVD outcome 39.3% 33.9% NS
At least 1 traditional CVD risk factor 90.9% 86.9% NS
≥3 traditional CVD risk factors 36.4% 32% NS
Atrial fibrillation 12% 7.9% NS
Extra-articular manifestations 8.9% 8.1% NS
Another autoimmune disease 20% 14% NS
Rheumatoid Arthritis Characteristics
RA disease duration (years) 12.2±9.6 11.8±8.8 NS
RF + 56.5% 77.5% p <0.05
ACPA + 70.6% 69.8% NS
Either RF + or ACPA + 89.5% 86.7% NS
Pos RF and Pos ACPA 58.8% 53.2% NS
ANA positive 47.1% 39.4% NS
CRP >10 * 71.4% 62.5% NS
ESR rate >42 ** 81.5% 61.8% p <0.05
Abnormal hand radiographs 95.2% 94.7% NS
Joint space narrowing 61.9% 69.9% NS
Presence of Joint erosions 66.6% 66.8% NS
SENS (±SD) 25.4±18.5 31.0±21.7 NS
Steroids only 51.1% 56.6% NS
Methotrexate 31.9% 41.3% NS
Other DMARD 52.6% 41.9% NS
Only Biologics 14.3% 16.5% NS
Steroids + any DMARD/Biologics 30.3% 36.2% NS
Only DMARD/Biologics 30.3% 26.3% NS