| Author, year | Country | Subjects | Age/sex matched | Results | COPD as DD risk | Quality score |
| Kubota et al, 2016 | Japan | Total: 230; COPD: 115 | Y | High E/e` as an index of severe LVDD was significantly higher in the COPD group than in the control group. E/e' significantly correlated to pulmonary function tests. | Y | 2/1/2 |
| Boussuges et al, 2000 | France | Total: 54; COPD: 34 | Y | E/A ratio was significantly lower in patients with COPD (P: 0.02). The transmitral flow pattern exhibited a dominant A wave with inverse E/A ratio (E/A) in 26 patients with COPD (76%) and in only seven control subjects (35%) (P: 0.003, chi-square test). | Y | 3/1/2 |
| Farouk et al, 2017 | Egypt | Total: 53; COPD: 35 | Y | LV diastolic dysfunction was reported in 20 patients using the mitral inflow indexes while in only 12 patients using the comprehensive approach (P=.021). | Y | 4/1/2 |
| Malerba et al, 2011 | Italy | Total: 95; COPD: 55 | Y | High E/e` as an index of severe LVDD was significantly higher in the COPD group than in the control group. | Y | 4/1/2 |
| Huang et al, 2014 | China | Total: 148; COPD: 75 | Y | Compared with the control group, the E/e' ratio was significantly higher in the COPD group (11.51±2.50 vs 10.42±3.25, P=0.047). A high frequency of LVDD was observed in patients with COPD (65.6%), but there was no difference among different stages of COPD. | Y | 3/1/2 |
| Eweda et al, 2015 | Egypt | Total: 60; COPD: 40 | Y | LVDD is related to the severity of COPD. Mitral A in the severe COPD group (P<0.001) was increased compared to the control. Lateral and septal E' were also decreased (p<0.001). Mitral E/A in severe COPD (P<0.001) was decreased compared to the control. IVRT in the severe COPD group (P<0.001) was increased compared to the control. | Y | 3/1/2 |
| Faludi et al, 2016 | Hungary | Total: 99; COPD: 65 | Y | Lateral and septal e' were lower in the COPD group (8.7±1.9 and 7.0±1.4) compared to the control group (11.1±3.1 and 9.0±2.1). The mean LV E/e' was higher in COPD patients (8.8±2.1) vs controls (6.4±1.4). E/A in the COPD group (0.9±0.2) was lower than in the control group (1.3±0.3) LVDD was found in 48 (74%) of COPD patients. LV filling pressure was elevated in 28 (43%) COPD patients. | Y | 4/1/2 |
| Sabit et al, 2010 | UK | Total: 50; COPD: 36 | Y | E/Ea of the COPD group (10.7±2.6) was increased compared to the control (7.9±1.6, p<0.01). IVRT of the COPD group (125±15.2) was increased compared to the control (98.2±21.1, p<0.01). COPD patients had increased RV myocardial relaxation time (P<0.001). Log10-IL-6 was related to pulmonary acceleration time and mitral annular E/A. | Y | 3/1/2 |
| Pela et al, 2016 | Italy | Total: 85; COPD: 49 | Y | The COPD patients had decreased LV size (P<0.05) and increased relative wall thickness (RWT) (P<0.001) compared to controls, indicating concentric remodeling of the left ventricle. RWT was significantly associated with FEV1/FVC and was the only cardiac parameter associated with COPD. RV E' tvi (p=0.01), and E'/A' tvi (p<0.05) were significantly decreased compared to the control. | Y | 3/1/2 |
| Yilmaz et al, 2005 | Turkey | Total: 68; COPD: 44 | Y | Tricuspid E/A was decreased in COPD subjects (p<0.002) and IVRT in COPD patients w/ and w/o PH was increased compared to the control (p<0.022, 0.001, respectively). By looking at LVMPI as a marker of both diastolic and systolic function, both may be imparied in COPD, especially in patients with PH. LVMPI was independently associated with PASP and FEV1. | Y | 4/1/3 |
| El Wahsh et al, 2013 | Egypt | Total: 48; COPD: 36 | Y | COPD patients had LVDD and LV global dysfunction. COPD patients had a higher HR, less E wave peak velocity (p<0.05), a smaller E/A ratio compared to control subjects. There was a significant difference in E wave peak velocity by flow and DTI, E/A by DTI, IVRT, and MPI between mild and very severe COPD. There were statisticallhy significant changes in LVDD based on severity of COPD. | Y | 4/1/3 |
| Funk et al, 2008 | US | Total: 44; COPD: 22 | Y | LV E max was decreased in COPD patients compared to controls (p<0.001). A max was increased in COPD patients (p<0.0001). E/A was decreased in COPD patients (p<0.0001). Observed correlation between E/A and A% with FEV1 and PaO2. Observed correlation between mPAP and E/A ratio. Observed that COPD patients with and without pulmonary hypertension had impaired LV diastolic filling. | Y | 3/1/3 |
| Suchon et al, 2007 | Poland | Total: 60; COPD: 35 | Y | E/A was significantly lower in COPD patients (p<0.001). E/A and RVSP were inversely correlated (-0.61; p<0.001). IVRT was significantly longer compared to the control (p<0.001). | Y | 3/1/2 |
| Acharya et al, 2013 | India | Total: 100 | Y | There were no statistically significant differences between Mitral E/A among the studied groups (p=0.183). There was a statistically significant difference between Septal E/E' and Lateral E/E' between cases and controls (p=0.003 and p<0.001 respectively). Prolonged IVRT in COPD group compared to controls. | Y | 2/1/2 |
| Abo El-Magd, 2017 | Egypt | Total: 80; COPD: 60 | Y | Regarding IVRT, DT of the early transmitral flow, E and A waves; there was significant statstical significance between COPD stage III/IV cmpared to stage stage 1/II and compared to the control group. | Y | 3/1/2 |