Field | Items | Occupations | have no idea | do not know much about | well, I know | know enough | Crude p value*1 | Adjusted p value*2 |
Cancer breakthrough pain | Definition of cancer breakthrough pain | Physicians (n = 25) | 0 (0) | 0 (0) | 18 (72) | 7 (28) | <.0001 | <.0001 |
Nurses (n = 76) | 13 (17.1) | 25 (32.9) | 29 (38.2) | 9 (11.8) |
Pharmacists (n = 77) | 1 (1.3) | 7 (9.1) | 42 (54.5) | 27 (35.1) |
Frequency of cancer breakthrough pain episodes per day | Physicians (n = 25) | 0 (0) | 6 (24) | 13 (52) | 6 (24) | 0.0015 | 0.018 |
Nurses (n = 76) | 15 (19.7) | 30 (39.5) | 26 (34.2) | 5 (6.6) |
Pharmacists (n = 77) | 1 (1.3) | 21 (27.3) | 44 (57.1) | 11 (14.3) |
Type of cancer breakthrough pain (predictable and spontaneous) | Physicians (n = 25) | 0 (0) | 5 (20) | 15 (60) | 5 (20) | 0.0188 | 0.2256 |
Nurses (n = 76) | 12 (15.8) | 27 (35.5) | 29 (38.2) | 8 (10.5) |
Pharmacists (n = 77) | 2 (2.6) | 13 (16.9) | 43 (55.8) | 19 (24.6) |
Duration of cancer breakthrough pain | Physicians (n = 25) | 0 (0) | 7 (28) | 13 (52) | 5 (20) | 0.0097 | 0.1164 |
Nurses (n = 76) | 16 (21.1) | 30 (42.9) | 24 (34.2) | 6 (7.9) |
Pharmacists (n = 77) | 4 (5.2) | 19 (24.7) | 38 (49.4) | 16 (20.8) |
Dosage and administration | Starting dose | Physicians (n = 25) | 2 (8) | 1 (4) | 10 (40) | 12 (48) | <.0001 | <.0001 |
Nurses (n = 76) | 12 (15.8) | 27 (35.5) | 31 (40.8) | 6 (7.9) |
Pharmacists (n = 77) | 3 (3.9) | 9 (11.6) | 36 (46.8) | 29 (37.7) |
Starting dose does not depend on the daily dose of the opioid analgesic being administered on time | Physicians (n = 25) | 2 (8) | 2 (8) | 5 (20) | 16 (64) | <.0001 | <.0001 |
Nurses (n = 76) | 15 (19.7) | 24 (31.6) | 29 (41.4) | 8 (10.5) |
Pharmacists (n = 77) | 1 (1.3) | 8 (10.4) | 39 (50.6) | 29 (37.7) |
How to adjust the dosage | Physicians (n = 25) | 2 (8) | 3 (12) | 13 (52) | 7 (28) | 0.0042 | 0.0504 |
Nurses (n = 76) | 15 (19.7) | 26 (34.2) | 28 (36.8) | 7 (9.2) |
Pharmacists (n = 77) | 2 (2.6) | 15 (19.5) | 43 (55.8) | 17 (22.1) |
Upper limit of single dose | Physicians (n = 25) | 3 (12) | 3 (12) | 11 (44) | 8 (32) | 0.0400 | 0.4800 |
Nurses (n = 76) | 13 (17.1) | 26 (34.2) | 27 (35.5) | 10 (13.2) |
Pharmacists (n = 77) | 4 (5.2) | 11 (14.3) | 43 (55.8) | 19 (24.7) |
Restriction of the number of doses | Physicians (n = 25) | 3 (12) | 4 (16) | 8 (32) | 10 (40) | 0.0516 | 0.6192 |
Nurses (n = 76) | 12 (15.8) | 25 (32.9) | 25 (32.9) | 14 (18.4) |
Pharmacists (n = 77) | 3 (3.9) | 12 (15.6) | 39 (50.6) | 23 (29.9) |
Pharmacokinetics | Time of onset of effect | Physicians (n = 25) | 2 (8) | 0 (0) | 15 (60) | 8 (32) | 0.0826 | 0.9912 |
Nurses (n = 76) | 9 (11.8) | 18 (23.7) | 39 (51.3) | 10 (13.2) |
Pharmacists (n = 77) | 2 (2.6) | 10 (13) | 41 (53.2) | 24 (31.6) |
Duration of effect | Physicians (n = 25) | 2 (8) | 3 (12) | 13 (52) | 7 (28) | 0.0998 | 1.0000 |
Nurses (n = 76) | 10 (13.2) | 20 (26.3) | 40 (52.6) | 6 (7.9) |
Pharmacists (n = 77) | 3 (3.9) | 19 (24.7) | 33 (42.9) | 22 (28.6) |
Medication instructions | Drug intake method (E-fen® buccal tablets) | Physicians (n = 25) | 3 (12) | 9 (36) | 6 (24) | 7 (28) | 0.0497 | 0.5964 |
Nurses (n = 76) | 19 (25) | 29 (38.2) | 23 (30.3) | 5 (6.6) |
Pharmacists (n = 77) | 8 (10.4) | 18 (23.4) | 32 (41.6) | 19 (24.7) |
Drug intake method (Abstral® sublingual tablets) | Physicians (n = 25) | 5 (20) | 5 (20) | 7 (28) | 8 (32) | 0.3603 | 1.0000 |
Nurses (n = 76) | 10 (13.2) | 17 (22.4) | 36 (47.3) | 13 (17.1) |
Pharmacists (n = 77) | 6 (7.8) | 10 (13) | 40 (51.9) | 21 (27.3) |
Side effect | Somnolence | Physicians (n = 25) | 2 (8) | 2 (8) | 9 (36) | 12 (48) | 0.0282 | 0.3384 |
Nurses (n = 76) | 7 (9.2) | 17 (22.4) | 36 (47.4) | 16 (21.1) |
Pharmacists (n = 77) | 1 (1.3) | 4 (5.2) | 40 (51.9) | 32 (41.6) |
Nausea / vomiting | Physicians (n = 25) | 2 (8) | 2 (8) | 9 (36) | 12 (48) | 0.0073 | 0.0876 |
Nurses (n = 76) | 7 (9.2) | 17 (22.4) | 38 (50) | 14 (18.4) |
Pharmacists (n = 77) | 1 (1.3) | 3 (3.9) | 40 (51.9) | 33 (42.9) |
Constipation | Physicians (n = 25) | 2 (8) | 2 (8) | 9 (36) | 12 (48) | 0.0013 | 0.0156 |
Nurses (n = 76) | 7 (9.2) | 21 (27.6) | 34 (44.7) | 14 (18.4) |
Pharmacists (n = 77) | 1 (1.3) | 3 (3.9) | 40 (51.9) | 33 (42.9) |
Side effects that are more likely to occur due to stomatitis or oral bleeding | Physicians (n = 25) | 2 (8) | 4 (16) | 12 (48) | 7 (28) | 0.1721 | 1.0000 |
Nurses (n = 76) | 9 (11.8) | 29 (38.2) | 28 (36.8) | 10 (13.2) |
Pharmacists (n = 77) | 2 (2.6) | 16 (20.8) | 36 (46.8) | 23 (29.9) |
Drug price | Approximate cost | Physicians (n = 25) | 9 (36) | 8 (32) | 4 (16) | 4 (16) | 0.0069 | 0.0828 |
Nurses (n = 76) | 40 (52.6) | 26 (34.2) | 8 (10.5) | 2 (2.6) |
Pharmacists (n = 77) | 19 (24.7) | 26 (33.8) | 23 (29.9) | 9 (11.7) |