Enzymes | Metabolites | Metabolite activity | |
Bosutinib | CYP3A4 | Oxide chlorinated derivative (M2) Demethylated derivative (M5) | Very reduced Very reduced |
Dasatinib | CYP3A4 | Oxide derivatives Derivatives conjugated with glucoronic acid | Inactive |
Imatinib | CYP3A4, CYP1A2, CYP2D6, CYP2C9, CYP2C19 | N-desmetilimatinib | Similar to imatinib |
Nilotinib | CYP3A4, CYP2C8, UGT1A1 | Oxide derivatives Derivatives conjugated with glucoronic acid | Probably inactive |
Ponatinib | Amidases, esterases CYP3A4, CYP2C8, CYP2D6, CYP3A5 | N-demethylated | Inferior |