Table 5: Inhibitory activity of CYP3A4 and transport proteins.
(1): No inhibitory effect.
(2): IC50: Inhibitory concentration 50%.
Bosutinib Dasatinib Imatinib Nilotinib Ponatinib
P-glycoprotein (1) (2) (2) (2) 0.49 μM
BCRP (1) (2) (2) (2) (2) 0.03 μM
CYP2A6 (1) (2) 35 μM
CYP2D6 (1) (2) 7.5 μM (2) 1.46 μM
CYP3A4 (1) (2) 10 μM (2) 7.9 μM (2) 0.44 μM
CYP2C8 (1) (2) 12 μM (2) 34 μM (2) 0.23 μM
CYP2C9 (1) (2) 50 μM (2) 28 μM (2) 0.13 μM
UGT1A1 (1) (2) 0.19 μM
hOCT1 (2)