Figure 1: shows the clinical response to cisplatin and the expression of NER genes in tissues of ovarian cancer patients. Panels in A of the two figures show 4 genes: ERCC1, XPA, XPB and CSB expressed at low levels in platinum-sensitive tumors (responders). The same genes expressed at high levels in platinum-resistant patients are shown in the panels in B [27]. These data suggest that clinical resistance to platinum therapy is positively associated with expression of human DNA repair gene ERCC1 and other NER genes.