Figure 2: From plants to human therapies. Molecules shown (b) are examples of pharmacologically active constituents of lemon balm leaves or valerian roots (a), shown to act on GABAARs as positive modulators (c). This reinforces the GABA-induced neuronal inhibition (c) and facilitates the decrease of brain activity, thus ending in either sedation, anxiolysis, muscle relaxation, sleep enhancement or anticonvulsant activity (d).