Figure 2: A schematic model for the differentiation of mesenchymal stem cells into tissue-specific cells by specific transcriptional factors. Mesenchymal stem cells can differentiate into osteoblasts, chondrocytes, and adipocytes. Each differentiation program is regulated by specific transcription factors: Runx2/Osterix (pink and green arrows, respectively), Sox5/6/9 (pink arrow), MyoD family (green arrow), and PPARγ (black arrows), respectively.