Figure 4: High fructose metabolism in the liver, leads to enhance the rate of de novo lipogenesis and triglyceride (TG) synthesis, driven by the high flux of glycerol from glycerol-3-Phosphate and acyl portions from Acyl-CoA. Triglyceride synthesis [46] is likely to lead to hepatic accumulation of triglyceride, which has been shown to reduce hepatic insulin sensitivity, as well as increased the formation of VLDL particles due to higher substrate availability. Increasing Apolipoprotein B (apo B) stability and higher Microsomal Triglyceride Transfer Protein (MTP) are the critical factor for the assembly of the Very Low-Density Lipoprotein (VLDL). VLDL is considered to be one of the bad forms of cholesterol in the blood.