Figure 2: One-carbon metabolism (modified from Persichilli et al 2015)
Abbreviations: Met: Methionine; SAM: S-adenosylmethionine; SAH: S-adenosylhomocysteine; Hcy: Homocysteine; Cys: Cysteine; GSH: Glutathione; THF: Tetrahydrofolate; MTHF: Methyltetrahydrofolate; B12: Vitamin B12; B6: Vitamin B6. ADO: Adenosine. 1: Methionine adenosyltransferase (MAT); 2: Methyltransferase; 3: SAH-hydrolase (SAHH); 4: Cystathionine-β-synthase (CBS); 5: Methionine synthase; 6: Methylenetetrahydrofolate reductase (MTHFR).