Table 3: The combination test results of LCME and conventional antifungal drugs against clinical Scedosporium isolates.
^aCBS, Centraalbureau voor Schimmelcultures, Utrecht, The Netherlands.
^bLCME_alone, AMB_alone, CSP_alone, TRB_alone and VRC_alone, mean MICs of L-cysteine methyl ester hydrochloride, amphotericin B, caspofungin, terbinafine and voriconazole, respectively, when applied alone; LCME_comb, AMB_comb, CSP_comb, TRB_comb and VRC_comb, mean MICs of L-cysteine methyl ester hydrochloride, amphotericin B, caspofungin, terbinafine and voriconazole, respectively, when applied in combination.
^cFICI, fractional inhibitory concentration index value
^dNI, no interaction (0.5 < FICI ≤ 4); S, synergism (FICI ≤ 0.5) [17].
*The MICs of AMB, CSP, TRB and VRC were determined in a previous study of our research group [14].