| Case I (NMO-Related) | Case II (MS-Related) | Case III (MS-Related) | |
| Natural History | Relapsing Remitting | Relapsing Remitting | Progressive |
| Ocular | Anisocoria, RAPD on the left, Visual acuity was no light perception on the left eye and counting finger on visual | Visual blurring with near total recovery after attacks | Visual blurring with RAPD on the left pupil and bilateral CN VI palsy |
| Motor | Paroxysmal Spasm. Spastic quadriparesis worse in the lower limbs | Visual blurring with RAPD on the left pupil and bilateral CN VI palsy | Right upper limb weakness |
| CSF analysis | Faint oligo-clonal band | Not done | Pronounced Oligo-clonal band |
| Recovery | Yes | Near total | |
| Spinal MRI | Longitudinal extensive contiguous lesion >3 segments | Lesions are 3 but not contiguous | Extensive contiguous lesion <3 segment |
| Brain MRI | Clean brain and not fulfilling Barkhof criteria | Increased signal intensity in the region of centrum semiovale on flair sequence | Increased signal intensity in the region of centrum semiovale and peri-ventricular area on flair sequence |
| Dissemination in Time | Yes | Yes | No |
| Dissemination in Space | Yes | Yes |